Female Male 127 33 Least Middle Worst 64 66 30 Female Male Least 49 15 Middle 51 15 Worst 27 3 Gradual Sudden Least 43 20 1 Middle 5 58 2 Worst 0 22 7 Gradual Sudden Female 41 76 8 Male 7 24 2 ================================================================================================ All Patients -- Males = 33 , Females= 127 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 153 34 55 64 0.431 0.569 28 49 75 3.321 3.321 0.072 0.071 2 TPH2.hCV8376173 160 30 58 72 0.412 0.588 27 55 78 0.819 0.819 0.428 0.414 3 TPH2.hCV8376146 160 30 59 71 0.409 0.591 27 56 77 1.085 1.085 0.324 0.327 4 TPH2.hCV8376042 160 25 64 71 0.378 0.622 23 62 75 0.510 0.510 0.504 0.502 5 TPH2.hCV8872233 160 27 63 70 0.388 0.613 24 60 76 0.982 0.982 0.402 0.321 6 TPH2.hCV11407441 160 27 67 66 0.375 0.625 23 63 75 2.304 2.304 0.183 0.131 7 TPH2.hCV245410 160 45 38 77 0.522 0.478 44 37 80 0.203 0.203 0.635 0.638 8 SLC6A4.hCV1841702 160 30 60 70 0.406 0.594 26 56 77 1.387 1.387 0.258 0.252 9 SLC6A4.hCV7911132 159 33 58 68 0.421 0.579 28 53 78 2.404 2.404 0.149 0.143 10 SLC6A4.hCV7911143 159 67 32 60 0.610 0.390 59 24 76 6.803 6.803 0.011* 0.012* 11 MAOA.hCV8878813 160 75 31 54 0.637 0.363 65 21 74 11.645 11.645 0.001* 0.001* 12 MAOA.hCV8878819 160 32 77 51 0.359 0.641 21 66 74 15.153 15.153 0.000* 0.000* 13 MAOA.hCV8878818 159 31 77 51 0.355 0.645 20 66 73 14.300 14.300 0.000* 0.000* 14 MAOB.hCV15763403 157 14 109 34 0.197 0.803 6 101 50 15.746 15.746 0.000* 0.000* 15 MAOB.hCV15959461 158 14 88 56 0.266 0.734 11 85 62 1.336 1.336 0.309 0.306 16 MAOB.hCV8878790 158 52 44 62 0.525 0.475 44 36 79 7.180 7.180 0.009* 0.007* 17 TH.hCV243542 157 76 14 67 0.697 0.303 76 14 66 0.020 0.020 1.000 1.000 18 TH.hCV1843075 157 41 42 74 0.497 0.503 39 40 78 0.515 0.515 0.527 0.523 19 COMT.hCV11804650 158 58 21 79 0.617 0.383 60 23 75 0.532 0.532 0.500 0.506 20 COMT.hCV11804654 159 40 33 86 0.522 0.478 43 36 79 1.118 1.118 0.343 0.342 21 COMT.hCV2538746 160 22 59 79 0.384 0.616 24 61 76 0.300 0.300 0.614 0.738 22 COMT.hCV2538747 160 33 49 78 0.450 0.550 32 48 79 0.037 0.037 0.867 0.873 23 COMT.hCV2539306 160 50 30 80 0.563 0.438 51 31 79 0.040 0.040 0.878 1.000 24 COMT.hCV2539273 160 83 9 68 0.731 0.269 86 12 63 1.057 1.057 0.328 0.420 25 COMT.hCV3274705 155 88 4 63 0.771 0.229 92 8 55 3.531 3.531 0.068 0.071 26 POMC.hCV3227244 159 4 105 50 0.182 0.818 5 106 47 0.470 0.470 0.610 0.604 27 CRHR1.hCV2544843 159 30 40 89 0.469 0.531 35 45 79 2.443 2.443 0.110 0.152 28 CRHR1.CRHR1.7450777 158 3 94 61 0.212 0.788 7 98 53 3.817 3.817 0.061 0.059 29 CRHR1.hCV2544836 156 37 32 87 0.516 0.484 42 37 78 2.118 2.118 0.148 0.199 30 CRHR1.hCV2544830 156 21 46 89 0.420 0.580 28 53 76 4.567 4.567 0.032* 0.048* 31 CRHR1.hCV2257689 155 41 30 84 0.535 0.465 44 33 77 1.238 1.238 0.334 0.333 32 CRHR1.hCV1570087 158 41 28 89 0.541 0.459 46 33 78 2.848 2.848 0.109 0.111 33 CRHR2.hCV15872871 158 16 68 74 0.335 0.665 18 70 70 0.403 0.403 0.592 0.595 34 CRHR2.hCV11823513 159 26 57 76 0.403 0.597 26 57 76 0.006 0.006 1.000 1.000 35 CRHR2.hCV15960586 159 6 96 57 0.217 0.783 7 97 54 0.481 0.481 0.500 0.642 36 NR3C1.hCV11837659 159 12 112 35 0.186 0.814 5 105 48 11.733 11.733 0.001* 0.001* 37 NR3C1.hCV11159943 154 69 19 66 0.662 0.338 68 18 69 0.270 0.270 0.715 0.592 38 NR3C1.hCV8950988 159 12 112 35 0.186 0.814 5 105 48 11.733 11.733 0.000* 0.001* 39 NR3C1.hCV8950998 158 69 24 65 0.642 0.358 65 20 73 1.728 1.728 0.170 0.224 40 NR3C1.hCV1046361 156 112 8 36 0.833 0.167 108 4 43 4.468 4.468 0.043* 0.042* 41 NR3C1.hCV1046353 158 22 69 67 0.351 0.649 19 66 72 0.765 0.765 0.388 0.385 42 NR3C1.hCV1046360 156 67 24 65 0.638 0.362 63 20 72 1.503 1.503 0.230 0.227 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Female Patients -- Males = 0 , Females= 127 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 121 24 45 52 0.413 0.587 21 42 59 1.567 1.567 0.257 0.259 2 TPH2.hCV8376173 127 21 49 57 0.390 0.610 19 47 60 0.405 0.405 0.583 0.576 3 TPH2.hCV8376146 127 21 50 56 0.386 0.614 19 48 60 0.615 0.615 0.459 0.455 4 TPH2.hCV8376042 127 16 53 58 0.354 0.646 16 53 58 0.000 0.000 1.000 1.000 5 TPH2.hCV8872233 127 18 51 58 0.370 0.630 17 50 59 0.053 0.053 0.854 0.849 6 TPH2.hCV11407441 127 19 54 54 0.362 0.638 17 52 59 0.807 0.807 0.441 0.441 7 TPH2.hCV245410 127 31 31 65 0.500 0.500 32 32 64 0.071 0.071 0.867 0.860 8 SLC6A4.hCV1841702 127 24 45 58 0.417 0.583 22 43 62 0.472 0.472 0.584 0.472 9 SLC6A4.hCV7911132 126 27 48 51 0.417 0.583 22 43 61 3.529 3.529 0.069 0.067 10 SLC6A4.hCV7911143 126 55 26 45 0.615 0.385 48 19 60 7.610 7.610 0.006* 0.008* 11 MAOA.hCV8878813 127 54 19 54 0.638 0.362 52 17 59 0.807 0.807 0.446 0.441 12 MAOA.hCV8878819 127 20 56 51 0.358 0.642 16 52 58 2.038 2.038 0.119 0.176 13 MAOA.hCV8878818 126 19 56 51 0.353 0.647 16 53 58 1.640 1.640 0.177 0.241 14 MAOB.hCV15763403 126 8 84 34 0.198 0.802 5 81 40 2.899 2.899 0.097 0.094 15 MAOB.hCV15959461 127 6 65 56 0.268 0.732 9 68 50 1.972 1.972 0.180 0.255 16 MAOB.hCV8878790 127 35 30 62 0.520 0.480 34 29 63 0.062 0.062 0.857 0.859 17 TH.hCV243542 126 61 10 55 0.702 0.298 62 11 53 0.245 0.245 0.675 0.831 18 TH.hCV1843075 125 32 30 63 0.508 0.492 32 30 62 0.009 0.009 1.000 1.000 19 COMT.hCV11804650 127 47 18 62 0.614 0.386 48 19 60 0.115 0.115 0.851 0.852 20 COMT.hCV11804654 127 31 23 73 0.531 0.469 36 28 63 3.019 3.019 0.077 0.109 21 COMT.hCV2538746 127 19 46 62 0.394 0.606 20 47 61 0.065 0.065 0.850 0.854 22 COMT.hCV2538747 127 27 39 61 0.453 0.547 26 38 63 0.120 0.120 0.720 0.723 23 COMT.hCV2539306 127 39 25 63 0.555 0.445 39 25 63 0.002 0.002 1.000 1.000 24 COMT.hCV2539273 127 69 7 51 0.744 0.256 70 8 48 0.377 0.377 0.645 0.646 25 COMT.hCV3274705 125 73 3 49 0.780 0.220 76 6 43 2.527 2.527 0.116 0.188 26 POMC.hCV3227244 127 3 84 40 0.181 0.819 4 85 38 0.486 0.486 0.572 0.764 27 CRHR1.hCV2544843 127 23 31 73 0.469 0.531 28 36 63 3.019 3.019 0.072 0.109 28 CRHR1.CRHR1.7450777 126 2 73 51 0.218 0.782 6 77 43 4.366 4.366 0.037* 0.063 29 CRHR1.hCV2544836 124 29 24 71 0.520 0.480 34 29 62 2.680 2.680 0.104 0.149 30 CRHR1.hCV2544830 124 17 35 72 0.427 0.573 23 41 61 4.303 4.303 0.045* 0.046* 31 CRHR1.hCV2257689 123 30 24 69 0.524 0.476 34 28 61 1.910 1.910 0.148 0.207 32 CRHR1.hCV1570087 125 31 21 73 0.540 0.460 36 26 62 3.851 3.851 0.048* 0.071 33 CRHR2.hCV15872871 125 13 50 62 0.352 0.648 15 52 57 0.952 0.952 0.432 0.433 34 CRHR2.hCV11823513 126 22 42 62 0.421 0.579 22 42 61 0.012 0.012 1.000 1.000 35 CRHR2.hCV15960586 126 5 70 51 0.242 0.758 7 72 46 1.339 1.339 0.337 0.334 36 NR3C1.hCV11837659 126 7 92 27 0.163 0.837 3 88 34 5.743 5.743 0.010* 0.022* 37 NR3C1.hCV11159943 122 58 17 47 0.668 0.332 54 13 54 2.107 2.107 0.159 0.154 38 NR3C1.hCV8950988 127 7 93 27 0.161 0.839 3 89 34 5.854 5.854 0.008* 0.021* 39 NR3C1.hCV8950998 126 57 21 48 0.643 0.357 52 16 58 3.657 3.657 0.080 0.055 40 NR3C1.hCV1046361 124 91 5 28 0.847 0.153 89 3 32 2.090 2.090 0.168 0.161 41 NR3C1.hCV1046353 125 19 56 50 0.352 0.648 15 52 57 1.897 1.897 0.170 0.172 42 NR3C1.hCV1046360 124 54 22 48 0.629 0.371 49 17 58 3.608 3.608 0.082 0.057 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Male Patients -- Males = 33 , Females= 0 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 32 10 10 12 0.500 0.500 8 8 16 2.000 2.000 0.290 0.168 2 TPH2.hCV8376173 33 9 9 15 0.500 0.500 8 8 17 0.273 0.273 0.727 0.727 3 TPH2.hCV8376146 33 9 9 15 0.500 0.500 8 8 17 0.273 0.273 0.726 0.727 4 TPH2.hCV8376042 33 9 11 13 0.470 0.530 7 9 16 1.444 1.444 0.305 0.294 5 TPH2.hCV8872233 33 9 12 12 0.455 0.545 7 10 16 2.347 2.347 0.174 0.160 6 TPH2.hCV11407441 33 8 13 12 0.424 0.576 6 11 16 2.157 2.157 0.176 0.160 7 TPH2.hCV245410 33 14 7 12 0.606 0.394 12 5 16 1.877 1.877 0.280 0.166 8 SLC6A4.hCV1841702 33 6 15 12 0.364 0.636 4 13 15 1.515 1.515 0.270 0.261 9 SLC6A4.hCV7911132 33 6 10 17 0.439 0.561 6 10 16 0.069 0.069 1.000 1.000 10 SLC6A4.hCV7911143 33 12 6 15 0.591 0.409 12 6 16 0.118 0.118 0.714 0.727 11 MAOA.hCV8878813 33 21 12 0 0.636 0.364 13 4 15 33.000 33.000 0.000* 0.000* 12 MAOA.hCV8878819 33 12 21 0 0.364 0.636 4 13 15 33.000 33.000 0.000* 0.000* 13 MAOA.hCV8878818 33 12 21 0 0.364 0.636 4 13 15 33.000 33.000 0.000* 0.000* 14 MAOB.hCV15763403 31 6 25 0 0.194 0.806 1 20 10 31.000 31.000 0.000* 0.000* 15 MAOB.hCV15959461 31 8 23 0 0.258 0.742 2 17 12 31.000 31.000 0.000* 0.000* 16 MAOB.hCV8878790 31 17 14 0 0.548 0.452 9 6 15 31.000 31.000 0.000* 0.000* 17 TH.hCV243542 31 15 4 12 0.677 0.323 14 3 14 0.405 0.405 0.691 0.679 18 TH.hCV1843075 32 9 12 11 0.453 0.547 7 10 16 3.004 3.004 0.074 0.085 19 COMT.hCV11804650 31 11 3 17 0.629 0.371 12 4 14 0.950 0.950 0.452 0.457 20 COMT.hCV11804654 32 9 10 13 0.484 0.516 8 9 16 1.115 1.115 0.297 0.302 21 COMT.hCV2538746 33 3 13 17 0.348 0.652 4 14 15 0.597 0.597 0.457 0.702 22 COMT.hCV2538747 33 6 10 17 0.439 0.561 6 10 16 0.069 0.069 1.000 1.000 23 COMT.hCV2539306 33 11 5 17 0.591 0.409 12 6 16 0.142 0.142 0.718 1.000 24 COMT.hCV2539273 33 14 2 17 0.682 0.318 15 3 14 1.158 1.158 0.434 0.433 25 COMT.hCV3274705 30 15 1 14 0.733 0.267 16 2 12 1.120 1.120 0.390 0.638 26 POMC.hCV3227244 32 1 21 10 0.188 0.813 1 21 10 0.021 0.021 1.000 1.000 27 CRHR1.hCV2544843 32 7 9 16 0.469 0.531 7 9 16 0.000 0.000 1.000 1.000 28 CRHR1.CRHR1.7450777 32 1 21 10 0.188 0.813 1 21 10 0.021 0.021 1.000 1.000 29 CRHR1.hCV2544836 32 8 8 16 0.500 0.500 8 8 16 0.000 0.000 1.000 1.000 30 CRHR1.hCV2544830 32 4 11 17 0.391 0.609 5 12 15 0.430 0.430 0.475 0.714 31 CRHR1.hCV2257689 32 11 6 15 0.578 0.422 11 6 16 0.049 0.049 1.000 1.000 32 CRHR1.hCV1570087 33 10 7 16 0.545 0.455 10 7 16 0.016 0.016 1.000 1.000 33 CRHR2.hCV15872871 33 3 18 12 0.273 0.727 2 17 13 0.229 0.229 0.668 0.665 34 CRHR2.hCV11823513 33 4 15 14 0.333 0.667 4 15 15 0.068 0.068 1.000 0.715 35 CRHR2.hCV15960586 33 1 26 6 0.121 0.879 0 25 7 0.709 0.709 0.421 0.381 36 NR3C1.hCV11837659 33 5 20 8 0.273 0.727 2 17 13 4.991 4.991 0.040* 0.031* 37 NR3C1.hCV11159943 32 11 2 19 0.641 0.359 13 4 15 2.682 2.682 0.133 0.146 38 NR3C1.hCV8950988 32 5 19 8 0.281 0.719 3 17 13 4.661 4.661 0.073 0.036* 39 NR3C1.hCV8950998 32 12 3 17 0.641 0.359 13 4 15 0.757 0.757 0.448 0.699 40 NR3C1.hCV1046361 32 21 3 8 0.781 0.219 20 2 11 2.308 2.308 0.294 0.133 41 NR3C1.hCV1046353 33 3 13 17 0.348 0.652 4 14 15 0.597 0.597 0.459 0.702 42 NR3C1.hCV1046360 32 13 2 17 0.672 0.328 14 3 14 1.343 1.343 0.240 0.425 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Worst Patients -- Males = 3 , Females= 27 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 29 2 15 12 0.276 0.724 2 15 12 0.037 0.037 1.000 1.000 2 TPH2.hCV8376173 30 3 14 13 0.317 0.683 3 14 13 0.000 0.000 1.000 1.000 3 TPH2.hCV8376146 30 3 14 13 0.317 0.683 3 14 13 0.000 0.000 1.000 1.000 4 TPH2.hCV8376042 30 2 15 13 0.283 0.717 2 15 12 0.135 0.135 1.000 1.000 5 TPH2.hCV8872233 30 3 14 13 0.317 0.683 3 14 13 0.000 0.000 1.000 1.000 6 TPH2.hCV11407441 30 3 16 11 0.283 0.717 2 15 12 0.283 0.283 0.682 0.655 7 TPH2.hCV245410 30 5 9 16 0.433 0.567 6 10 15 0.222 0.222 0.722 1.000 8 SLC6A4.hCV1841702 30 4 10 16 0.400 0.600 5 11 14 0.370 0.370 0.705 0.711 9 SLC6A4.hCV7911132 30 10 7 13 0.550 0.450 9 6 15 0.466 0.466 0.467 0.481 10 SLC6A4.hCV7911143 30 11 7 12 0.567 0.433 10 6 15 1.033 1.033 0.457 0.454 11 MAOA.hCV8878813 30 12 6 12 0.600 0.400 11 5 14 0.833 0.833 0.466 0.447 12 MAOA.hCV8878819 30 6 12 12 0.400 0.600 5 11 14 0.833 0.833 0.450 0.447 13 MAOA.hCV8878818 30 6 12 12 0.400 0.600 5 11 14 0.833 0.833 0.456 0.447 14 MAOB.hCV15763403 28 0 19 9 0.161 0.839 1 20 8 1.027 1.027 0.559 1.000 15 MAOB.hCV15959461 29 1 11 17 0.328 0.672 3 13 13 3.170 3.170 0.099 0.198 16 MAOB.hCV8878790 29 7 6 16 0.517 0.483 8 7 14 0.318 0.318 0.717 0.719 17 TH.hCV243542 29 17 2 10 0.759 0.241 17 2 11 0.099 0.099 1.000 0.644 18 TH.hCV1843075 30 9 8 13 0.517 0.483 8 7 15 0.526 0.526 0.471 0.479 19 COMT.hCV11804650 29 11 3 15 0.638 0.362 12 4 13 0.415 0.415 0.697 0.697 20 COMT.hCV11804654 30 4 6 20 0.467 0.533 7 9 15 3.453 3.453 0.084 0.139 21 COMT.hCV2538746 30 3 11 16 0.367 0.633 4 12 14 0.660 0.660 0.468 0.694 22 COMT.hCV2538747 30 5 10 15 0.417 0.583 5 10 15 0.024 0.024 1.000 1.000 23 COMT.hCV2539306 30 9 5 16 0.567 0.433 10 6 15 0.222 0.222 0.727 1.000 24 COMT.hCV2539273 30 16 0 14 0.767 0.233 18 2 11 2.779 2.779 0.152 0.295 25 COMT.hCV3274705 30 17 0 13 0.783 0.217 18 1 10 2.295 2.295 0.153 0.291 26 POMC.hCV3227244 29 1 20 8 0.172 0.828 1 20 8 0.032 0.032 1.000 1.000 27 CRHR1.hCV2544843 30 6 8 16 0.467 0.533 7 9 15 0.153 0.153 0.732 1.000 28 CRHR1.CRHR1.7450777 30 0 21 9 0.150 0.850 1 22 8 0.934 0.934 0.556 1.000 29 CRHR1.hCV2544836 28 5 6 17 0.482 0.518 7 8 14 1.304 1.304 0.250 0.448 30 CRHR1.hCV2544830 29 3 8 18 0.414 0.586 5 10 14 2.264 2.264 0.250 0.250 31 CRHR1.hCV2257689 29 8 7 14 0.517 0.483 8 7 14 0.032 0.032 1.000 1.000 32 CRHR1.hCV1570087 30 8 6 16 0.533 0.467 9 7 15 0.153 0.153 0.730 1.000 33 CRHR2.hCV15872871 30 3 16 11 0.283 0.717 2 15 12 0.283 0.283 0.684 0.655 34 CRHR2.hCV11823513 30 5 9 16 0.433 0.567 6 10 15 0.222 0.222 0.721 1.000 35 CRHR2.hCV15960586 30 1 17 12 0.233 0.767 2 18 11 0.418 0.418 0.655 1.000 36 NR3C1.hCV11837659 30 1 24 5 0.117 0.883 0 23 6 1.099 1.099 0.079 0.325 37 NR3C1.hCV11159943 29 18 1 10 0.793 0.207 18 1 10 0.075 0.075 1.000 1.000 38 NR3C1.hCV8950988 30 1 24 5 0.117 0.883 0 23 6 1.099 1.099 0.075 0.325 39 NR3C1.hCV8950998 30 17 4 9 0.717 0.283 15 2 12 2.048 2.048 0.204 0.179 40 NR3C1.hCV1046361 30 24 1 5 0.883 0.117 23 0 6 1.099 1.099 0.077 0.325 41 NR3C1.hCV1046353 29 3 16 10 0.276 0.724 2 15 12 0.544 0.544 0.643 0.638 42 NR3C1.hCV1046360 30 18 3 9 0.750 0.250 17 2 11 1.200 1.200 0.402 0.327 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Worst Female Patients -- Males = 0 , Females= 27 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 26 2 14 10 0.269 0.731 2 14 10 0.013 0.013 1.000 1.000 2 TPH2.hCV8376173 27 3 13 11 0.315 0.685 3 13 12 0.084 0.084 1.000 0.683 3 TPH2.hCV8376146 27 3 13 11 0.315 0.685 3 13 12 0.084 0.084 1.000 0.683 4 TPH2.hCV8376042 27 2 14 11 0.278 0.722 2 14 11 0.006 0.006 1.000 1.000 5 TPH2.hCV8872233 27 3 13 11 0.315 0.685 3 13 12 0.084 0.084 1.000 0.683 6 TPH2.hCV11407441 27 2 15 10 0.259 0.741 2 15 10 0.034 0.034 1.000 1.000 7 TPH2.hCV245410 27 5 8 14 0.444 0.556 5 8 13 0.068 0.067 1.000 1.000 8 SLC6A4.hCV1841702 27 4 8 15 0.426 0.574 5 9 13 0.500 0.500 0.441 0.697 9 SLC6A4.hCV7911132 27 7 7 13 0.500 0.500 7 7 14 0.037 0.037 1.000 1.000 10 SLC6A4.hCV7911143 27 11 5 11 0.611 0.389 10 4 13 0.551 0.551 0.438 0.443 11 MAOA.hCV8878813 27 11 4 12 0.630 0.370 11 4 13 0.060 0.060 1.000 1.000 12 MAOA.hCV8878819 27 4 11 12 0.370 0.630 4 11 13 0.060 0.060 1.000 1.000 13 MAOA.hCV8878818 27 4 11 12 0.370 0.630 4 11 13 0.060 0.060 1.000 1.000 14 MAOB.hCV15763403 26 0 17 9 0.173 0.827 1 18 7 1.139 1.139 0.538 1.000 15 MAOB.hCV15959461 27 0 10 17 0.315 0.685 3 13 12 5.700 5.700 0.025* 0.028* 16 MAOB.hCV8878790 27 6 5 16 0.519 0.481 7 6 13 0.942 0.942 0.459 0.456 17 TH.hCV243542 27 16 2 9 0.759 0.241 16 2 10 0.210 0.210 0.631 0.614 18 TH.hCV1843075 27 7 8 12 0.481 0.519 6 7 13 0.326 0.326 0.703 0.700 19 COMT.hCV11804650 27 11 3 13 0.648 0.352 11 3 12 0.084 0.084 1.000 1.000 20 COMT.hCV11804654 27 2 6 19 0.426 0.574 5 9 13 5.203 5.203 0.020* 0.048* 21 COMT.hCV2538746 27 3 10 14 0.370 0.630 4 11 13 0.337 0.337 0.693 0.698 22 COMT.hCV2538747 27 5 10 12 0.407 0.593 4 9 13 0.171 0.171 0.712 0.699 23 COMT.hCV2539306 27 9 5 13 0.574 0.426 9 5 13 0.006 0.006 1.000 1.000 24 COMT.hCV2539273 27 16 0 11 0.796 0.204 17 1 9 1.767 1.767 0.289 0.549 25 COMT.hCV3274705 27 17 0 10 0.815 0.185 18 1 8 1.395 1.395 0.549 0.549 26 POMC.hCV3227244 27 1 18 8 0.185 0.815 1 18 8 0.009 0.009 1.000 1.000 27 CRHR1.hCV2544843 27 6 8 13 0.463 0.537 6 8 13 0.027 0.027 1.000 1.000 28 CRHR1.CRHR1.7450777 27 0 18 9 0.167 0.833 1 19 8 1.080 1.080 0.553 1.000 29 CRHR1.hCV2544836 26 5 6 15 0.481 0.519 6 7 13 0.629 0.629 0.436 0.694 30 CRHR1.hCV2544830 26 3 6 17 0.442 0.558 5 8 13 2.752 2.752 0.115 0.228 31 CRHR1.hCV2257689 26 8 7 11 0.519 0.481 7 6 13 0.605 0.605 0.439 0.449 32 CRHR1.hCV1570087 27 8 6 13 0.537 0.463 8 6 13 0.027 0.027 1.000 1.000 33 CRHR2.hCV15872871 27 3 14 10 0.296 0.704 2 13 11 0.338 0.338 0.662 0.646 34 CRHR2.hCV11823513 27 5 8 14 0.444 0.556 5 8 13 0.068 0.067 1.000 1.000 35 CRHR2.hCV15960586 27 1 15 11 0.241 0.759 2 16 10 0.354 0.354 0.633 1.000 36 NR3C1.hCV11837659 27 1 22 4 0.111 0.889 0 21 5 1.688 1.688 0.309 0.266 37 NR3C1.hCV11159943 26 18 1 7 0.827 0.173 18 1 7 0.092 0.092 1.000 0.565 38 NR3C1.hCV8950988 27 1 22 4 0.111 0.889 0 21 5 1.688 1.688 0.308 0.266 39 NR3C1.hCV8950998 27 17 3 7 0.759 0.241 16 2 10 2.283 2.283 0.138 0.135 40 NR3C1.hCV1046361 27 21 1 5 0.870 0.130 20 0 6 0.868 0.868 0.595 0.358 41 NR3C1.hCV1046353 26 2 16 8 0.231 0.769 1 15 9 0.462 0.462 0.593 0.578 42 NR3C1.hCV1046360 27 16 3 8 0.741 0.259 15 2 10 1.411 1.411 0.331 0.309 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick Patients (Worst + Middle) -- Males = 18 , Females= 78 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 94 22 36 36 0.426 0.574 17 31 46 4.413 4.413 0.059 0.036* 2 TPH2.hCV8376173 96 19 36 41 0.411 0.589 16 33 46 1.341 1.341 0.206 0.291 3 TPH2.hCV8376146 96 19 37 40 0.406 0.594 16 34 46 1.784 1.784 0.204 0.205 4 TPH2.hCV8376042 96 16 41 39 0.370 0.630 13 38 45 1.582 1.582 0.190 0.197 5 TPH2.hCV8872233 96 17 39 40 0.385 0.615 14 36 45 1.393 1.393 0.282 0.280 6 TPH2.hCV11407441 96 16 42 38 0.365 0.635 13 39 44 2.037 2.037 0.187 0.185 7 TPH2.hCV245410 96 27 23 46 0.521 0.479 26 22 48 0.154 0.154 0.842 0.686 8 SLC6A4.hCV1841702 96 16 33 47 0.411 0.589 16 33 46 0.011 0.011 1.000 1.000 9 SLC6A4.hCV7911132 95 19 28 48 0.453 0.547 19 28 47 0.037 0.037 1.000 1.000 10 SLC6A4.hCV7911143 96 35 19 42 0.583 0.417 33 17 47 0.960 0.960 0.394 0.400 11 MAOA.hCV8878813 96 40 19 37 0.609 0.391 36 15 46 3.481 3.481 0.054 0.085 12 MAOA.hCV8878819 96 19 41 36 0.385 0.615 14 36 45 4.170 4.170 0.057 0.051 13 MAOA.hCV8878818 95 19 41 35 0.384 0.616 14 36 45 4.657 4.657 0.030* 0.032* 14 MAOB.hCV15763403 94 8 62 24 0.213 0.787 4 58 31 5.317 5.317 0.031* 0.028* 15 MAOB.hCV15959461 95 7 54 34 0.253 0.747 6 53 36 0.259 0.259 0.783 0.592 16 MAOB.hCV8878790 95 29 28 38 0.505 0.495 24 23 47 3.797 3.797 0.065 0.064 17 TH.hCV243542 94 42 5 47 0.697 0.303 46 9 40 3.160 3.160 0.091 0.093 18 TH.hCV1843075 94 28 24 42 0.521 0.479 26 22 47 1.032 1.032 0.412 0.307 19 COMT.hCV11804650 95 37 11 47 0.637 0.363 39 13 44 0.460 0.460 0.513 0.657 20 COMT.hCV11804654 95 23 20 52 0.516 0.484 25 22 47 0.872 0.872 0.408 0.415 21 COMT.hCV2538746 96 12 37 47 0.370 0.630 13 38 45 0.244 0.244 0.662 0.826 22 COMT.hCV2538747 96 17 32 47 0.422 0.578 17 32 47 0.001 0.001 1.000 1.000 23 COMT.hCV2539306 96 32 16 48 0.583 0.417 33 17 47 0.078 0.078 0.831 0.837 24 COMT.hCV2539273 96 45 5 46 0.708 0.292 48 8 40 2.447 2.447 0.148 0.145 25 COMT.hCV3274705 95 48 4 43 0.732 0.268 51 7 37 2.209 2.209 0.197 0.193 26 POMC.hCV3227244 95 4 63 28 0.189 0.811 3 62 29 0.155 0.155 0.745 0.737 27 CRHR1.hCV2544843 95 20 23 52 0.484 0.516 22 25 47 0.872 0.872 0.421 0.415 28 CRHR1.CRHR1.7450777 95 1 59 35 0.195 0.805 4 62 30 2.900 2.900 0.110 0.183 29 CRHR1.hCV2544836 93 23 20 50 0.516 0.484 25 22 46 0.543 0.543 0.540 0.537 30 CRHR1.hCV2544830 94 12 27 55 0.420 0.580 17 32 46 3.790 3.790 0.058 0.089 31 CRHR1.hCV2257689 93 23 20 50 0.516 0.484 25 22 46 0.543 0.543 0.531 0.537 32 CRHR1.hCV1570087 95 24 18 53 0.532 0.468 27 21 47 1.374 1.374 0.220 0.305 33 CRHR2.hCV15872871 95 13 42 40 0.347 0.653 11 40 43 0.484 0.484 0.507 0.500 34 CRHR2.hCV11823513 96 17 31 48 0.427 0.573 18 32 47 0.045 0.045 0.841 1.000 35 CRHR2.hCV15960586 96 5 55 36 0.240 0.760 6 56 35 0.082 0.082 0.796 1.000 36 NR3C1.hCV11837659 96 6 71 19 0.161 0.839 3 68 26 6.951 6.951 0.004* 0.015* 37 NR3C1.hCV11159943 92 48 10 34 0.707 0.293 46 8 38 1.090 1.090 0.322 0.316 38 NR3C1.hCV8950988 96 6 71 19 0.161 0.839 3 68 26 6.951 6.951 0.005* 0.015* 39 NR3C1.hCV8950998 94 48 13 33 0.686 0.314 44 9 40 3.212 3.212 0.055 0.092 40 NR3C1.hCV1046361 94 71 5 18 0.851 0.149 68 2 24 5.626 5.626 0.035* 0.028* 41 NR3C1.hCV1046353 94 12 47 35 0.314 0.686 9 44 40 1.725 1.725 0.153 0.229 42 NR3C1.hCV1046360 95 48 12 35 0.689 0.311 45 9 41 1.851 1.851 0.151 0.228 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick Female Patients (Worst + Middle) -- Males = 0 , Females= 78 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 77 16 30 31 0.409 0.591 13 27 37 2.155 2.155 0.163 0.158 2 TPH2.hCV8376173 78 14 31 33 0.391 0.609 12 29 37 0.972 0.972 0.347 0.344 3 TPH2.hCV8376146 78 14 32 32 0.385 0.615 12 30 37 1.387 1.387 0.335 0.238 4 TPH2.hCV8376042 78 10 35 33 0.340 0.660 9 34 35 0.253 0.253 0.617 0.618 5 TPH2.hCV8872233 78 11 33 34 0.359 0.641 10 32 36 0.218 0.218 0.806 0.628 6 TPH2.hCV11407441 78 10 36 32 0.333 0.667 9 35 35 0.462 0.462 0.608 0.609 7 TPH2.hCV245410 78 21 19 38 0.513 0.487 21 19 39 0.049 0.049 1.000 0.823 8 SLC6A4.hCV1841702 78 14 26 38 0.423 0.577 14 26 38 0.000 0.000 1.000 1.000 9 SLC6A4.hCV7911132 77 15 25 37 0.435 0.565 15 25 38 0.039 0.039 0.819 0.820 10 SLC6A4.hCV7911143 78 31 16 31 0.596 0.404 28 13 38 2.378 2.378 0.102 0.157 11 MAOA.hCV8878813 78 30 11 37 0.622 0.378 30 11 37 0.006 0.006 1.000 1.000 12 MAOA.hCV8878819 78 11 31 36 0.372 0.628 11 31 36 0.011 0.011 1.000 1.000 13 MAOA.hCV8878818 77 11 31 35 0.370 0.630 11 31 36 0.049 0.049 0.811 0.810 14 MAOB.hCV15763403 77 4 49 24 0.208 0.792 3 48 25 0.219 0.219 0.734 0.727 15 MAOB.hCV15959461 78 2 42 34 0.244 0.756 5 45 29 2.609 2.609 0.134 0.136 16 MAOB.hCV8878790 78 21 19 38 0.513 0.487 21 19 39 0.049 0.049 1.000 0.823 17 TH.hCV243542 78 35 5 38 0.692 0.308 37 7 33 1.607 1.607 0.292 0.290 18 TH.hCV1843075 76 23 17 36 0.539 0.461 22 16 38 0.166 0.166 0.810 0.652 19 COMT.hCV11804650 78 30 10 38 0.628 0.372 31 11 36 0.144 0.144 0.805 0.811 20 COMT.hCV11804654 78 18 15 45 0.519 0.481 21 18 39 1.887 1.887 0.167 0.256 21 COMT.hCV2538746 78 11 29 38 0.385 0.615 12 30 37 0.066 0.066 0.817 1.000 22 COMT.hCV2538747 78 15 25 38 0.436 0.564 15 25 38 0.007 0.007 1.000 1.000 23 COMT.hCV2539306 78 25 14 39 0.571 0.429 25 14 38 0.032 0.032 1.000 1.000 24 COMT.hCV2539273 78 40 4 34 0.731 0.269 42 6 31 0.906 0.906 0.401 0.563 25 COMT.hCV3274705 77 42 3 32 0.753 0.247 44 5 29 1.072 1.072 0.376 0.537 26 POMC.hCV3227244 78 3 52 23 0.186 0.814 3 52 24 0.052 0.052 0.725 0.718 27 CRHR1.hCV2544843 78 16 20 42 0.474 0.526 18 22 39 0.496 0.496 0.501 0.649 28 CRHR1.CRHR1.7450777 78 0 48 30 0.192 0.808 3 51 24 4.422 4.422 0.061 0.060 29 CRHR1.hCV2544836 76 19 17 40 0.513 0.487 20 18 38 0.216 0.216 0.661 0.818 30 CRHR1.hCV2544830 76 10 21 45 0.428 0.572 14 25 37 3.337 3.337 0.059 0.101 31 CRHR1.hCV2257689 76 19 17 40 0.513 0.487 20 18 38 0.216 0.216 0.647 0.818 32 CRHR1.hCV1570087 77 20 14 43 0.539 0.461 22 16 38 1.178 1.178 0.253 0.361 33 CRHR2.hCV15872871 77 11 32 34 0.364 0.636 10 31 36 0.162 0.162 0.800 0.805 34 CRHR2.hCV11823513 78 15 23 40 0.449 0.551 16 24 39 0.104 0.104 0.823 0.822 35 CRHR2.hCV15960586 78 4 43 31 0.250 0.750 5 44 29 0.279 0.279 0.769 0.766 36 NR3C1.hCV11837659 78 4 60 14 0.141 0.859 2 58 19 5.239 5.239 0.045* 0.037* 37 NR3C1.hCV11159943 75 42 9 24 0.720 0.280 39 6 30 3.193 3.193 0.091 0.085 38 NR3C1.hCV8950988 78 4 60 14 0.141 0.859 2 58 19 5.239 5.239 0.043* 0.037* 39 NR3C1.hCV8950998 77 41 11 25 0.695 0.305 37 7 33 4.232 4.232 0.028* 0.057 40 NR3C1.hCV1046361 77 59 4 14 0.857 0.143 57 2 19 5.109 5.109 0.045* 0.039* 41 NR3C1.hCV1046353 76 10 39 27 0.309 0.691 7 36 32 2.155 2.155 0.116 0.177 42 NR3C1.hCV1046360 77 38 12 27 0.669 0.331 34 8 34 3.346 3.346 0.076 0.073 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick Male Patients (Worst + Middle) -- Males = 18 , Females= 0 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 17 6 6 5 0.500 0.500 4 4 9 2.882 2.882 0.154 0.141 2 TPH2.hCV8376173 18 5 5 8 0.500 0.500 5 5 9 0.222 0.222 1.000 0.654 3 TPH2.hCV8376146 18 5 5 8 0.500 0.500 5 5 9 0.222 0.222 1.000 0.654 4 TPH2.hCV8376042 18 6 6 6 0.500 0.500 5 5 9 2.000 2.000 0.338 0.176 5 TPH2.hCV8872233 18 6 6 6 0.500 0.500 5 5 9 2.000 2.000 0.345 0.176 6 TPH2.hCV11407441 18 6 6 6 0.500 0.500 5 5 9 2.000 2.000 0.351 0.176 7 TPH2.hCV245410 18 6 4 8 0.556 0.444 6 4 9 0.180 0.180 1.000 0.657 8 SLC6A4.hCV1841702 18 2 7 9 0.361 0.639 2 7 8 0.126 0.126 1.000 1.000 9 SLC6A4.hCV7911132 18 4 3 11 0.528 0.472 5 4 9 0.919 0.919 0.344 0.635 10 SLC6A4.hCV7911143 18 4 3 11 0.528 0.472 5 4 9 0.919 0.919 0.347 0.635 11 MAOA.hCV8878813 18 10 8 0 0.556 0.444 6 4 9 18.000 18.000 0.000* 0.000* 12 MAOA.hCV8878819 18 8 10 0 0.444 0.556 4 6 9 18.000 18.000 0.000* 0.000* 13 MAOA.hCV8878818 18 8 10 0 0.444 0.556 4 6 9 18.000 18.000 0.000* 0.000* 14 MAOB.hCV15763403 17 4 13 0 0.235 0.765 1 10 6 17.000 17.000 0.000* 0.000* 15 MAOB.hCV15959461 17 5 12 0 0.294 0.706 1 8 7 17.000 17.000 0.000* 0.000* 16 MAOB.hCV8878790 17 8 9 0 0.471 0.529 4 5 8 17.000 17.000 0.000* 0.000* 17 TH.hCV243542 16 7 0 9 0.719 0.281 8 1 6 2.450 2.450 0.243 0.256 18 TH.hCV1843075 18 5 7 6 0.444 0.556 4 6 9 1.901 1.901 0.338 0.179 19 COMT.hCV11804650 17 7 1 9 0.676 0.324 8 2 7 0.746 0.746 0.605 0.608 20 COMT.hCV11804654 17 5 5 7 0.500 0.500 4 4 9 0.529 0.529 0.637 0.627 21 COMT.hCV2538746 18 1 8 9 0.306 0.694 2 9 8 0.571 0.571 0.605 1.000 22 COMT.hCV2538747 18 2 7 9 0.361 0.639 2 7 8 0.126 0.126 1.000 1.000 23 COMT.hCV2539306 18 7 2 9 0.639 0.361 7 2 8 0.126 0.126 1.000 1.000 24 COMT.hCV2539273 18 5 1 12 0.611 0.389 7 3 9 2.918 2.918 0.150 0.161 25 COMT.hCV3274705 18 6 1 11 0.639 0.361 7 2 8 1.894 1.894 0.151 0.321 26 POMC.hCV3227244 17 1 11 5 0.206 0.794 1 11 6 0.172 0.172 1.000 0.537 27 CRHR1.hCV2544843 17 4 3 10 0.529 0.471 5 4 8 0.554 0.554 0.632 0.644 28 CRHR1.CRHR1.7450777 17 1 11 5 0.206 0.794 1 11 6 0.172 0.172 1.000 0.537 29 CRHR1.hCV2544836 17 4 3 10 0.529 0.471 5 4 8 0.554 0.554 0.646 0.644 30 CRHR1.hCV2544830 18 2 6 10 0.389 0.611 3 7 9 0.513 0.513 0.640 0.646 31 CRHR1.hCV2257689 17 4 3 10 0.529 0.471 5 4 8 0.554 0.554 0.644 0.644 32 CRHR1.hCV1570087 18 4 4 10 0.500 0.500 5 5 9 0.222 0.222 1.000 1.000 33 CRHR2.hCV15872871 18 2 10 6 0.278 0.722 1 9 7 0.516 0.516 0.593 0.559 34 CRHR2.hCV11823513 18 2 8 8 0.333 0.667 2 8 8 0.000 0.000 1.000 1.000 35 CRHR2.hCV15960586 18 1 12 5 0.194 0.806 1 12 6 0.231 0.231 0.521 0.512 36 NR3C1.hCV11837659 18 2 11 5 0.250 0.750 1 10 7 1.210 1.210 0.249 0.260 37 NR3C1.hCV11159943 17 6 1 10 0.647 0.353 7 2 8 1.409 1.409 0.332 0.591 38 NR3C1.hCV8950988 18 2 11 5 0.250 0.750 1 10 7 1.210 1.210 0.243 0.260 39 NR3C1.hCV8950998 17 7 2 8 0.647 0.353 7 2 8 0.016 0.016 1.000 1.000 40 NR3C1.hCV1046361 17 12 1 4 0.824 0.176 12 1 5 0.617 0.617 1.000 0.411 41 NR3C1.hCV1046353 18 2 8 8 0.333 0.667 2 8 8 0.000 0.000 1.000 1.000 42 NR3C1.hCV1046360 18 10 0 8 0.778 0.222 11 1 6 1.469 1.469 0.529 0.529 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick + Sudden Onset -- Males = 1 , Females= 8 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 8 2 4 2 0.375 0.625 1 3 4 1.742 1.742 0.462 0.217 2 TPH2.hCV8376173 9 3 3 3 0.500 0.500 2 2 5 1.000 1.000 0.521 0.502 3 TPH2.hCV8376146 9 3 3 3 0.500 0.500 2 2 5 1.000 1.000 0.521 0.502 4 TPH2.hCV8376042 9 2 4 3 0.389 0.611 1 3 4 0.803 0.803 0.531 0.493 5 TPH2.hCV8872233 9 3 3 3 0.500 0.500 2 2 5 1.000 1.000 0.528 0.502 6 TPH2.hCV11407441 9 2 5 2 0.333 0.667 1 4 4 2.250 2.250 0.467 0.167 7 TPH2.hCV245410 9 4 2 3 0.611 0.389 3 1 4 0.803 0.803 0.530 0.493 8 SLC6A4.hCV1841702 9 0 2 7 0.389 0.611 1 3 4 3.645 3.645 0.047* 0.176 9 SLC6A4.hCV7911132 9 1 5 3 0.278 0.722 1 5 4 0.258 0.258 1.000 0.529 10 SLC6A4.hCV7911143 9 4 0 5 0.722 0.278 5 1 4 1.331 1.331 0.463 1.000 11 MAOA.hCV8878813 9 1 3 5 0.389 0.611 1 3 4 0.257 0.257 1.000 1.000 12 MAOA.hCV8878819 9 3 1 5 0.611 0.389 3 1 4 0.257 0.257 1.000 1.000 13 MAOA.hCV8878818 9 3 1 5 0.611 0.389 3 1 4 0.257 0.257 1.000 1.000 14 MAOB.hCV15763403 9 0 7 2 0.111 0.889 0 7 2 0.141 0.141 1.000 1.000 15 MAOB.hCV15959461 9 0 5 4 0.222 0.778 0 5 3 0.735 0.735 1.000 1.000 16 MAOB.hCV8878790 9 3 0 6 0.667 0.333 4 1 4 2.250 2.250 0.464 0.457 17 TH.hCV243542 8 4 1 3 0.688 0.313 4 1 3 0.130 0.130 1.000 1.000 18 TH.hCV1843075 9 3 3 3 0.500 0.500 2 2 5 1.000 1.000 0.529 0.502 19 COMT.hCV11804650 9 4 1 4 0.667 0.333 4 1 4 0.000 0.000 1.000 1.000 20 COMT.hCV11804654 9 0 1 8 0.444 0.556 2 3 4 5.760 5.760 0.042* 0.056 21 COMT.hCV2538746 9 1 4 4 0.333 0.667 1 4 4 0.000 0.000 1.000 1.000 22 COMT.hCV2538747 9 1 4 4 0.333 0.667 1 4 4 0.000 0.000 1.000 1.000 23 COMT.hCV2539306 9 4 1 4 0.667 0.333 4 1 4 0.000 0.000 1.000 1.000 24 COMT.hCV2539273 9 5 0 4 0.778 0.222 5 0 3 0.735 0.735 1.000 1.000 25 COMT.hCV3274705 9 6 0 3 0.833 0.167 6 0 2 0.360 0.360 1.000 1.000 26 POMC.hCV3227244 9 1 7 1 0.167 0.833 0 6 3 3.240 3.240 0.029* 0.176 27 CRHR1.hCV2544843 8 2 1 5 0.563 0.438 3 2 4 0.583 0.583 0.486 1.000 28 CRHR1.CRHR1.7450777 9 0 7 2 0.111 0.889 0 7 2 0.141 0.141 1.000 1.000 29 CRHR1.hCV2544836 9 1 3 5 0.389 0.611 1 3 4 0.257 0.257 1.000 1.000 30 CRHR1.hCV2544830 9 0 0 9 0.500 0.500 2 2 5 9.000 9.000 0.008* 0.011* 31 CRHR1.hCV2257689 9 2 3 4 0.444 0.556 2 3 4 0.090 0.090 1.000 1.000 32 CRHR1.hCV1570087 9 2 2 5 0.500 0.500 2 2 5 0.111 0.111 1.000 1.000 33 CRHR2.hCV15872871 9 2 4 3 0.389 0.611 1 3 4 0.803 0.803 0.521 0.493 34 CRHR2.hCV11823513 9 3 2 4 0.556 0.444 3 2 4 0.090 0.090 1.000 1.000 35 CRHR2.hCV15960586 9 0 5 4 0.222 0.778 0 5 3 0.735 0.735 1.000 1.000 36 NR3C1.hCV11837659 9 1 7 1 0.167 0.833 0 6 3 3.240 3.240 0.026* 0.176 37 NR3C1.hCV11159943 9 4 1 4 0.667 0.333 4 1 4 0.000 0.000 1.000 1.000 38 NR3C1.hCV8950988 9 1 7 1 0.167 0.833 0 6 3 3.240 3.240 0.026* 0.176 39 NR3C1.hCV8950998 9 4 1 4 0.667 0.333 4 1 4 0.000 0.000 1.000 1.000 40 NR3C1.hCV1046361 9 7 0 2 0.889 0.111 7 0 2 0.141 0.141 1.000 1.000 41 NR3C1.hCV1046353 9 1 4 4 0.333 0.667 1 4 4 0.000 0.000 1.000 1.000 42 NR3C1.hCV1046360 9 5 1 3 0.722 0.278 5 1 4 0.258 0.258 1.000 0.529 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick + Gradual Onset -- Males = 16 , Females= 64 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 79 19 29 31 0.437 0.563 15 25 39 3.237 3.237 0.067 0.071 2 TPH2.hCV8376173 80 15 30 35 0.406 0.594 13 28 39 0.694 0.694 0.360 0.486 3 TPH2.hCV8376146 80 15 31 34 0.400 0.600 13 29 38 1.050 1.050 0.361 0.351 4 TPH2.hCV8376042 80 14 34 32 0.375 0.625 11 31 38 1.721 1.721 0.235 0.232 5 TPH2.hCV8872233 80 14 33 33 0.381 0.619 12 31 38 1.264 1.264 0.232 0.247 6 TPH2.hCV11407441 80 14 34 32 0.375 0.625 11 31 38 1.721 1.721 0.238 0.232 7 TPH2.hCV245410 80 22 19 39 0.519 0.481 22 19 40 0.045 0.045 0.821 0.825 8 SLC6A4.hCV1841702 80 13 28 39 0.406 0.594 13 28 39 0.009 0.009 1.000 1.000 9 SLC6A4.hCV7911132 79 16 22 41 0.462 0.538 17 23 39 0.153 0.153 0.655 0.822 10 SLC6A4.hCV7911143 80 26 17 37 0.556 0.444 25 16 39 0.319 0.319 0.654 0.650 11 MAOA.hCV8878813 80 36 15 29 0.631 0.369 32 11 37 3.920 3.920 0.058 0.055 12 MAOA.hCV8878819 80 15 37 28 0.362 0.637 11 33 37 4.713 4.713 0.052 0.031* 13 MAOA.hCV8878818 79 15 37 27 0.361 0.639 10 32 36 5.299 5.299 0.016* 0.027* 14 MAOB.hCV15763403 78 8 50 20 0.231 0.769 4 46 28 6.019 6.019 0.024* 0.021* 15 MAOB.hCV15959461 79 7 44 28 0.266 0.734 6 43 31 0.668 0.668 0.561 0.396 16 MAOB.hCV8878790 79 22 27 30 0.468 0.532 17 22 39 4.454 4.454 0.046* 0.042* 17 TH.hCV243542 79 35 4 40 0.696 0.304 38 7 33 3.065 3.065 0.109 0.112 18 TH.hCV1843075 79 21 20 38 0.506 0.494 20 19 39 0.113 0.113 0.820 0.822 19 COMT.hCV11804650 79 29 9 41 0.627 0.373 31 11 37 0.940 0.940 0.335 0.470 20 COMT.hCV11804654 79 21 17 41 0.525 0.475 22 18 39 0.130 0.130 0.827 0.823 21 COMT.hCV2538746 80 10 29 41 0.381 0.619 12 31 38 0.595 0.595 0.483 0.635 22 COMT.hCV2538747 80 15 24 41 0.444 0.556 16 25 39 0.116 0.116 0.826 0.823 23 COMT.hCV2539306 80 24 14 42 0.563 0.438 25 15 39 0.356 0.356 0.652 0.652 24 COMT.hCV2539273 80 37 5 38 0.700 0.300 39 7 34 1.372 1.372 0.292 0.298 25 COMT.hCV3274705 80 39 4 37 0.719 0.281 41 6 32 1.658 1.658 0.277 0.273 26 POMC.hCV3227244 79 3 49 27 0.209 0.791 3 49 26 0.092 0.092 1.000 1.000 27 CRHR1.hCV2544843 80 18 18 44 0.500 0.500 20 20 40 0.800 0.800 0.500 0.502 28 CRHR1.CRHR1.7450777 79 0 49 30 0.190 0.810 3 52 24 4.340 4.340 0.062 0.060 29 CRHR1.hCV2544836 77 19 17 41 0.513 0.487 20 18 38 0.332 0.332 0.647 0.652 30 CRHR1.hCV2544830 78 10 26 42 0.397 0.603 12 28 37 1.204 1.204 0.356 0.348 31 CRHR1.hCV2257689 77 18 17 42 0.506 0.494 20 19 38 0.639 0.639 0.495 0.499 32 CRHR1.hCV1570087 79 18 16 45 0.513 0.487 21 19 39 1.548 1.548 0.270 0.265 33 CRHR2.hCV15872871 79 10 36 33 0.335 0.665 9 35 35 0.314 0.314 0.625 0.615 34 CRHR2.hCV11823513 80 12 27 41 0.406 0.594 13 28 39 0.311 0.311 0.646 0.649 35 CRHR2.hCV15960586 80 4 47 29 0.231 0.769 4 47 28 0.031 0.031 1.000 1.000 36 NR3C1.hCV11837659 80 4 61 15 0.144 0.856 2 59 20 4.544 4.544 0.015* 0.048* 37 NR3C1.hCV11159943 76 41 8 27 0.717 0.283 39 6 31 1.176 1.176 0.265 0.268 38 NR3C1.hCV8950988 80 4 61 15 0.144 0.856 2 59 20 4.544 4.544 0.014* 0.048* 39 NR3C1.hCV8950998 78 41 11 26 0.692 0.308 37 7 33 3.693 3.693 0.065 0.063 40 NR3C1.hCV1046361 78 61 4 13 0.865 0.135 58 1 18 6.320 6.320 0.008* 0.026* 41 NR3C1.hCV1046353 78 10 40 28 0.308 0.692 7 37 33 1.933 1.933 0.191 0.184 42 NR3C1.hCV1046360 79 40 10 29 0.690 0.310 38 8 34 1.595 1.595 0.195 0.198 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick Females + Sudden Onset -- Males = 0 , Females= 8 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 7 1 4 2 0.286 0.714 1 4 3 0.630 0.630 1.000 0.441 2 TPH2.hCV8376173 8 2 3 3 0.438 0.563 2 3 4 0.454 0.454 0.476 0.530 3 TPH2.hCV8376146 8 2 3 3 0.438 0.563 2 3 4 0.454 0.454 0.484 0.530 4 TPH2.hCV8376042 8 1 4 3 0.313 0.688 1 4 3 0.130 0.130 1.000 1.000 5 TPH2.hCV8872233 8 2 3 3 0.438 0.563 2 3 4 0.454 0.454 0.487 0.530 6 TPH2.hCV11407441 8 1 5 2 0.250 0.750 1 5 3 0.889 0.889 1.000 0.385 7 TPH2.hCV245410 8 3 2 3 0.563 0.438 3 2 4 0.454 0.454 0.485 0.530 8 SLC6A4.hCV1841702 8 0 2 6 0.375 0.625 1 3 4 2.880 2.880 0.198 0.441 9 SLC6A4.hCV7911132 8 1 4 3 0.313 0.688 1 4 3 0.130 0.130 1.000 1.000 10 SLC6A4.hCV7911143 8 3 0 5 0.688 0.313 4 1 3 1.653 1.653 0.453 0.487 11 MAOA.hCV8878813 8 1 2 5 0.438 0.563 2 3 4 0.583 0.583 0.485 1.000 12 MAOA.hCV8878819 8 2 1 5 0.563 0.438 3 2 4 0.583 0.583 0.486 1.000 13 MAOA.hCV8878818 8 2 1 5 0.563 0.438 3 2 4 0.583 0.583 0.486 1.000 14 MAOB.hCV15763403 8 0 6 2 0.125 0.875 0 6 2 0.163 0.163 1.000 1.000 15 MAOB.hCV15959461 8 0 4 4 0.250 0.750 1 5 3 0.889 0.889 1.000 1.000 16 MAOB.hCV8878790 8 2 0 6 0.625 0.375 3 1 4 2.880 2.880 0.200 0.441 17 TH.hCV243542 8 4 1 3 0.688 0.313 4 1 3 0.130 0.130 1.000 1.000 18 TH.hCV1843075 8 3 2 3 0.563 0.438 3 2 4 0.454 0.454 0.487 0.530 19 COMT.hCV11804650 8 3 1 4 0.625 0.375 3 1 4 0.036 0.036 1.000 1.000 20 COMT.hCV11804654 8 0 1 7 0.438 0.563 2 3 4 4.840 4.840 0.031* 0.138 21 COMT.hCV2538746 8 1 3 4 0.375 0.625 1 3 4 0.036 0.036 1.000 1.000 22 COMT.hCV2538747 8 1 3 4 0.375 0.625 1 3 4 0.036 0.036 1.000 1.000 23 COMT.hCV2539306 8 3 1 4 0.625 0.375 3 1 4 0.036 0.036 1.000 1.000 24 COMT.hCV2539273 8 5 0 3 0.813 0.188 5 0 2 0.426 0.426 1.000 1.000 25 COMT.hCV3274705 8 6 0 2 0.875 0.125 6 0 2 0.163 0.163 1.000 1.000 26 POMC.hCV3227244 8 1 7 0 0.125 0.875 0 6 2 8.000 8.000 0.125 0.067 27 CRHR1.hCV2544843 8 2 1 5 0.563 0.438 3 2 4 0.583 0.583 0.491 1.000 28 CRHR1.CRHR1.7450777 8 0 7 1 0.063 0.938 0 7 1 0.036 0.036 1.000 1.000 29 CRHR1.hCV2544836 8 0 3 5 0.313 0.688 1 4 3 1.653 1.653 0.474 0.487 30 CRHR1.hCV2544830 8 0 0 8 0.500 0.500 2 2 4 8.000 8.000 0.031* 0.025* 31 CRHR1.hCV2257689 8 1 3 4 0.375 0.625 1 3 4 0.036 0.036 1.000 1.000 32 CRHR1.hCV1570087 8 1 2 5 0.438 0.563 2 3 4 0.583 0.583 0.483 1.000 33 CRHR2.hCV15872871 8 2 3 3 0.438 0.563 2 3 4 0.454 0.454 0.484 0.530 34 CRHR2.hCV11823513 8 3 1 4 0.625 0.375 3 1 4 0.036 0.036 1.000 1.000 35 CRHR2.hCV15960586 8 0 4 4 0.250 0.750 1 5 3 0.889 0.889 1.000 1.000 36 NR3C1.hCV11837659 8 0 7 1 0.063 0.938 0 7 1 0.036 0.036 1.000 1.000 37 NR3C1.hCV11159943 8 4 1 3 0.688 0.313 4 1 3 0.130 0.130 1.000 1.000 38 NR3C1.hCV8950988 8 0 7 1 0.063 0.938 0 7 1 0.036 0.036 1.000 1.000 39 NR3C1.hCV8950998 8 4 1 3 0.688 0.313 4 1 3 0.130 0.130 1.000 1.000 40 NR3C1.hCV1046361 8 7 0 1 0.938 0.063 7 0 1 0.036 0.036 1.000 1.000 41 NR3C1.hCV1046353 8 1 4 3 0.313 0.688 1 4 3 0.130 0.130 1.000 1.000 42 NR3C1.hCV1046360 8 5 1 2 0.750 0.250 5 1 3 0.889 0.889 1.000 0.385 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Sick Females + Gradual Onset -- Males = 0 , Females= 64 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 64 14 23 27 0.430 0.570 12 21 31 1.241 1.241 0.315 0.308 2 TPH2.hCV8376173 64 11 25 28 0.391 0.609 10 24 30 0.420 0.420 0.609 0.599 3 TPH2.hCV8376146 64 11 26 27 0.383 0.617 9 24 30 0.736 0.736 0.425 0.429 4 TPH2.hCV8376042 64 9 28 27 0.352 0.648 8 27 29 0.357 0.357 0.589 0.586 5 TPH2.hCV8872233 64 9 27 28 0.359 0.641 8 26 29 0.159 0.159 0.791 0.786 6 TPH2.hCV11407441 64 9 28 27 0.352 0.648 8 27 29 0.357 0.357 0.597 0.586 7 TPH2.hCV245410 64 17 15 32 0.516 0.484 17 15 32 0.000 0.000 1.000 1.000 8 SLC6A4.hCV1841702 64 11 22 31 0.414 0.586 11 22 31 0.000 0.000 1.000 1.000 9 SLC6A4.hCV7911132 63 12 21 30 0.429 0.571 12 21 31 0.049 0.049 1.000 0.801 10 SLC6A4.hCV7911143 64 24 14 26 0.578 0.422 21 11 31 1.788 1.788 0.204 0.202 11 MAOA.hCV8878813 64 27 8 29 0.648 0.352 27 8 29 0.002 0.002 1.000 1.000 12 MAOA.hCV8878819 64 8 28 28 0.344 0.656 8 28 29 0.059 0.059 1.000 0.786 13 MAOA.hCV8878818 63 8 28 27 0.341 0.659 7 27 28 0.138 0.138 0.783 0.780 14 MAOB.hCV15763403 63 4 39 20 0.222 0.778 3 38 22 0.420 0.420 0.719 0.478 15 MAOB.hCV15959461 64 2 34 28 0.250 0.750 4 36 24 1.778 1.778 0.311 0.316 16 MAOB.hCV8878790 64 16 18 30 0.484 0.516 15 17 32 0.243 0.243 0.806 0.622 17 TH.hCV243542 64 28 4 32 0.688 0.313 30 6 28 1.714 1.714 0.252 0.254 18 TH.hCV1843075 63 17 14 32 0.524 0.476 17 14 31 0.021 0.021 1.000 1.000 19 COMT.hCV11804650 64 24 8 32 0.625 0.375 25 9 30 0.284 0.284 0.788 0.790 20 COMT.hCV11804654 64 16 13 35 0.523 0.477 18 15 32 0.592 0.592 0.451 0.616 21 COMT.hCV2538746 64 9 23 32 0.391 0.609 10 24 30 0.162 0.162 0.791 0.796 22 COMT.hCV2538747 64 13 19 32 0.453 0.547 13 19 32 0.005 0.005 1.000 1.000 23 COMT.hCV2539306 64 19 12 33 0.555 0.445 20 13 32 0.122 0.122 0.794 0.804 24 COMT.hCV2539273 64 32 4 28 0.719 0.281 33 5 26 0.432 0.432 0.563 0.757 25 COMT.hCV3274705 64 33 3 28 0.734 0.266 35 5 25 0.943 0.943 0.369 0.522 26 POMC.hCV3227244 64 2 39 23 0.211 0.789 3 40 21 0.405 0.405 0.720 0.717 27 CRHR1.hCV2544843 64 14 16 34 0.484 0.516 15 17 32 0.258 0.258 0.622 0.802 28 CRHR1.CRHR1.7450777 64 0 38 26 0.203 0.797 3 41 21 4.158 4.158 0.052 0.055 29 CRHR1.hCV2544836 62 17 14 31 0.524 0.476 17 14 31 0.000 0.000 1.000 1.000 30 CRHR1.hCV2544830 62 9 20 33 0.411 0.589 10 21 30 0.609 0.609 0.427 0.600 31 CRHR1.hCV2257689 62 16 14 32 0.516 0.484 17 15 31 0.069 0.069 0.801 1.000 32 CRHR1.hCV1570087 63 16 12 35 0.532 0.468 18 14 31 0.842 0.842 0.317 0.452 33 CRHR2.hCV15872871 63 8 27 28 0.349 0.651 8 27 29 0.031 0.031 1.000 1.000 34 CRHR2.hCV11823513 64 10 20 34 0.422 0.578 11 21 31 0.508 0.508 0.608 0.610 35 CRHR2.hCV15960586 64 3 37 24 0.234 0.766 4 38 23 0.129 0.129 0.756 1.000 36 NR3C1.hCV11837659 64 3 50 11 0.133 0.867 1 48 15 4.124 4.124 0.016* 0.066 37 NR3C1.hCV11159943 61 35 7 19 0.730 0.270 32 4 24 2.710 2.710 0.109 0.107 38 NR3C1.hCV8950988 64 3 50 11 0.133 0.867 1 48 15 4.124 4.124 0.018* 0.066 39 NR3C1.hCV8950998 63 34 9 20 0.698 0.302 31 6 27 3.825 3.825 0.072 0.069 40 NR3C1.hCV1046361 63 49 3 11 0.865 0.135 47 1 15 4.002 4.002 0.018* 0.069 41 NR3C1.hCV1046353 62 8 32 22 0.306 0.694 6 30 26 1.693 1.693 0.234 0.230 42 NR3C1.hCV1046360 63 30 10 23 0.659 0.341 27 7 28 2.227 2.227 0.170 0.160 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Least Group -- Males = 15 , Females= 49 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 59 12 19 28 0.441 0.559 11 18 29 0.082 0.082 0.798 0.794 2 TPH2.hCV8376173 64 11 22 31 0.414 0.586 11 22 31 0.000 0.000 1.000 1.000 3 TPH2.hCV8376146 64 11 22 31 0.414 0.586 11 22 31 0.000 0.000 1.000 1.000 4 TPH2.hCV8376042 64 9 23 32 0.391 0.609 10 24 30 0.162 0.162 0.788 0.796 5 TPH2.hCV8872233 64 10 24 30 0.391 0.609 10 24 30 0.015 0.015 1.000 1.000 6 TPH2.hCV11407441 64 11 25 28 0.391 0.609 10 24 30 0.420 0.420 0.599 0.599 7 TPH2.hCV245410 64 18 15 31 0.523 0.477 18 15 32 0.054 0.054 0.799 0.806 8 SLC6A4.hCV1841702 64 14 27 23 0.398 0.602 10 23 31 4.010 4.010 0.036* 0.066 9 SLC6A4.hCV7911132 64 14 30 20 0.375 0.625 9 25 30 7.111 7.111 0.016* 0.008* 10 SLC6A4.hCV7911143 63 32 13 18 0.651 0.349 27 8 29 8.690 8.690 0.005* 0.005* 11 MAOA.hCV8878813 64 35 12 17 0.680 0.320 30 7 28 9.733 9.733 0.002* 0.003* 12 MAOA.hCV8878819 64 13 36 15 0.320 0.680 7 30 28 13.645 13.645 0.000* 0.000* 13 MAOA.hCV8878818 64 12 36 16 0.313 0.688 6 30 28 11.192 11.192 0.001* 0.001* 14 MAOB.hCV15763403 63 6 47 10 0.175 0.825 2 43 18 12.718 12.718 0.002* 0.002* 15 MAOB.hCV15959461 63 7 34 22 0.286 0.714 5 32 26 1.314 1.314 0.352 0.233 16 MAOB.hCV8878790 63 23 16 24 0.556 0.444 19 12 31 3.291 3.291 0.082 0.076 17 TH.hCV243542 63 34 9 20 0.698 0.302 31 6 27 3.825 3.825 0.072 0.069 18 TH.hCV1843075 63 13 18 32 0.460 0.540 13 18 31 0.031 0.031 1.000 1.000 19 COMT.hCV11804650 63 21 10 32 0.587 0.413 22 11 31 0.144 0.144 0.797 0.799 20 COMT.hCV11804654 64 17 13 34 0.531 0.469 18 14 32 0.284 0.284 0.618 0.801 21 COMT.hCV2538746 64 10 22 32 0.406 0.594 11 23 31 0.085 0.085 0.805 1.000 22 COMT.hCV2538747 64 16 17 31 0.492 0.508 16 17 32 0.062 0.062 0.805 0.805 23 COMT.hCV2539306 64 18 14 32 0.531 0.469 18 14 32 0.001 0.001 1.000 1.000 24 COMT.hCV2539273 64 38 4 22 0.766 0.234 38 4 23 0.114 0.114 1.000 0.731 25 COMT.hCV3274705 60 40 0 20 0.833 0.167 42 2 17 2.400 2.400 0.186 0.339 26 POMC.hCV3227244 64 0 42 22 0.172 0.828 2 44 18 2.757 2.757 0.182 0.186 27 CRHR1.hCV2544843 64 10 17 37 0.445 0.555 13 20 32 1.855 1.855 0.211 0.215 28 CRHR1.CRHR1.7450777 63 2 35 26 0.238 0.762 4 37 23 1.191 1.191 0.328 0.485 29 CRHR1.hCV2544836 63 14 12 37 0.516 0.484 17 15 31 1.947 1.947 0.212 0.213 30 CRHR1.hCV2544830 62 9 19 34 0.419 0.581 11 21 30 0.985 0.985 0.429 0.436 31 CRHR1.hCV2257689 62 18 10 34 0.565 0.435 20 12 30 0.825 0.825 0.444 0.445 32 CRHR1.hCV1570087 63 17 10 36 0.556 0.444 19 12 31 1.556 1.556 0.308 0.308 33 CRHR2.hCV15872871 63 3 26 34 0.317 0.683 6 29 27 3.792 3.792 0.084 0.081 34 CRHR2.hCV11823513 63 9 26 28 0.365 0.635 8 25 29 0.107 0.107 0.788 0.787 35 CRHR2.hCV15960586 63 1 41 21 0.183 0.817 2 42 19 0.861 0.861 0.442 0.672 36 NR3C1.hCV11837659 63 6 41 16 0.222 0.778 3 38 22 4.434 4.434 0.063 0.059 37 NR3C1.hCV11159943 62 21 9 32 0.597 0.403 22 10 30 0.325 0.325 0.604 0.791 38 NR3C1.hCV8950988 63 6 41 16 0.222 0.778 3 38 22 4.434 4.434 0.064 0.059 39 NR3C1.hCV8950998 64 21 11 32 0.578 0.422 21 11 31 0.040 0.040 1.000 1.000 40 NR3C1.hCV1046361 62 41 3 18 0.806 0.194 40 2 19 0.304 0.304 0.685 0.680 41 NR3C1.hCV1046353 64 10 22 32 0.406 0.594 11 23 31 0.085 0.085 0.802 1.000 42 NR3C1.hCV1046360 61 19 12 30 0.557 0.443 19 12 30 0.001 0.001 1.000 1.000 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Least Female Group -- Males = 0 , Females= 49 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 44 8 15 21 0.420 0.580 8 15 21 0.019 0.019 1.000 1.000 2 TPH2.hCV8376173 49 7 18 24 0.388 0.612 7 18 23 0.049 0.049 1.000 1.000 3 TPH2.hCV8376146 49 7 18 24 0.388 0.612 7 18 23 0.049 0.049 1.000 1.000 4 TPH2.hCV8376042 49 6 18 25 0.378 0.622 7 19 23 0.358 0.358 0.550 0.761 5 TPH2.hCV8872233 49 7 18 24 0.388 0.612 7 18 23 0.049 0.049 1.000 1.000 6 TPH2.hCV11407441 49 9 18 22 0.408 0.592 8 17 24 0.245 0.245 0.774 0.767 7 TPH2.hCV245410 49 10 12 27 0.480 0.520 11 13 24 0.529 0.529 0.575 0.574 8 SLC6A4.hCV1841702 49 10 19 20 0.408 0.592 8 17 24 1.180 1.180 0.379 0.373 9 SLC6A4.hCV7911132 49 12 23 14 0.388 0.612 7 18 23 7.771 7.771 0.008* 0.006* 10 SLC6A4.hCV7911143 48 24 10 14 0.646 0.354 20 6 22 6.305 6.305 0.026* 0.013* 11 MAOA.hCV8878813 49 24 8 17 0.663 0.337 22 6 22 2.444 2.444 0.120 0.119 12 MAOA.hCV8878819 49 9 25 15 0.337 0.663 6 22 22 4.852 4.852 0.025* 0.029* 13 MAOA.hCV8878818 49 8 25 16 0.327 0.673 5 22 22 3.251 3.251 0.108 0.100 14 MAOB.hCV15763403 49 4 35 10 0.184 0.816 2 33 15 5.000 5.000 0.042* 0.038* 15 MAOB.hCV15959461 49 4 23 22 0.306 0.694 5 24 21 0.158 0.158 0.750 1.000 16 MAOB.hCV8878790 49 14 11 24 0.531 0.469 14 11 24 0.014 0.014 1.000 1.000 17 TH.hCV243542 48 26 5 17 0.719 0.281 25 4 19 0.738 0.738 0.300 0.473 18 TH.hCV1843075 49 9 13 27 0.459 0.541 10 14 24 0.587 0.587 0.396 0.569 19 COMT.hCV11804650 49 17 8 24 0.592 0.408 17 8 24 0.009 0.009 1.000 1.000 20 COMT.hCV11804654 49 13 8 28 0.551 0.449 15 10 24 1.175 1.175 0.389 0.389 21 COMT.hCV2538746 49 8 17 24 0.408 0.592 8 17 24 0.009 0.009 1.000 1.000 22 COMT.hCV2538747 49 12 14 23 0.480 0.520 11 13 24 0.174 0.174 0.776 0.775 23 COMT.hCV2539306 49 14 11 24 0.531 0.469 14 11 24 0.014 0.014 1.000 1.000 24 COMT.hCV2539273 49 29 3 17 0.765 0.235 29 3 18 0.057 0.057 1.000 0.707 25 COMT.hCV3274705 48 31 0 17 0.823 0.177 33 2 14 2.223 2.223 0.173 0.319 26 POMC.hCV3227244 49 0 32 17 0.173 0.827 1 33 14 2.158 2.158 0.173 0.320 27 CRHR1.hCV2544843 49 7 11 31 0.459 0.541 10 14 24 3.673 3.673 0.042* 0.086 28 CRHR1.CRHR1.7450777 48 2 25 21 0.260 0.740 3 26 18 0.885 0.885 0.465 0.473 29 CRHR1.hCV2544836 48 10 7 31 0.531 0.469 14 11 24 4.226 4.226 0.044* 0.080 30 CRHR1.hCV2544830 48 7 14 27 0.427 0.573 9 16 23 1.072 1.072 0.375 0.386 31 CRHR1.hCV2257689 47 11 7 29 0.543 0.457 14 10 23 2.776 2.776 0.077 0.145 32 CRHR1.hCV1570087 48 11 7 30 0.542 0.458 14 10 24 3.213 3.213 0.091 0.143 33 CRHR2.hCV15872871 48 2 18 28 0.333 0.667 5 21 21 4.687 4.688 0.049* 0.051 34 CRHR2.hCV11823513 48 7 19 22 0.375 0.625 7 19 23 0.024 0.024 1.000 1.000 35 CRHR2.hCV15960586 48 1 27 20 0.229 0.771 3 29 17 1.544 1.544 0.271 0.413 36 NR3C1.hCV11837659 48 3 32 13 0.198 0.802 2 31 15 1.037 1.037 0.180 0.356 37 NR3C1.hCV11159943 47 16 8 23 0.585 0.415 16 8 23 0.003 0.003 1.000 1.000 38 NR3C1.hCV8950988 49 3 33 13 0.194 0.806 2 32 15 1.121 1.121 0.185 0.351 39 NR3C1.hCV8950998 49 16 10 23 0.561 0.439 15 9 24 0.108 0.108 0.774 0.774 40 NR3C1.hCV1046361 47 32 1 14 0.830 0.170 32 1 13 0.140 0.140 1.000 1.000 41 NR3C1.hCV1046353 49 9 17 23 0.418 0.582 9 17 24 0.062 0.062 0.773 0.776 42 NR3C1.hCV1046360 47 16 10 21 0.564 0.436 15 9 23 0.394 0.394 0.549 0.558 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level ================================================================================================ Least Male Group -- Males = 15 , Females= 0 Hardy-Weinberg Equilibrium Analysis # SNP N N1 N2 N3 p q E1 E2 E3 chi sq HWE.chisq HWE.exact -- -------------------- --- --- --- --- ------ ------ --- --- --- ------ ------------- --------- 1 TPH2.hCV15836061 15 4 4 7 0.500 0.500 4 4 8 0.067 0.067 1.000 1.000 2 TPH2.hCV8376173 15 4 4 7 0.500 0.500 4 4 8 0.067 0.067 1.000 1.000 3 TPH2.hCV8376146 15 4 4 7 0.500 0.500 4 4 8 0.067 0.067 1.000 1.000 4 TPH2.hCV8376042 15 3 5 7 0.433 0.567 3 5 7 0.037 0.037 1.000 1.000 5 TPH2.hCV8872233 15 3 6 6 0.400 0.600 2 5 7 0.417 0.417 0.625 0.600 6 TPH2.hCV11407441 15 2 7 6 0.333 0.667 2 7 7 0.150 0.150 1.000 0.616 7 TPH2.hCV245410 15 8 3 4 0.667 0.333 7 2 7 2.400 2.400 0.254 0.232 8 SLC6A4.hCV1841702 15 4 8 3 0.367 0.633 2 6 7 4.863 4.863 0.027* 0.034* 9 SLC6A4.hCV7911132 15 2 7 6 0.333 0.667 2 7 7 0.150 0.150 1.000 0.616 10 SLC6A4.hCV7911143 15 8 3 4 0.667 0.333 7 2 7 2.400 2.400 0.247 0.232 11 MAOA.hCV8878813 15 11 4 0 0.733 0.267 8 1 6 15.000 15.000 0.001* 0.000* 12 MAOA.hCV8878819 15 4 11 0 0.267 0.733 1 8 6 15.000 15.000 0.001* 0.000* 13 MAOA.hCV8878818 15 4 11 0 0.267 0.733 1 8 6 15.000 15.000 0.001* 0.000* 14 MAOB.hCV15763403 14 2 12 0 0.143 0.857 0 10 3 14.000 14.000 0.012* 0.004* 15 MAOB.hCV15959461 14 3 11 0 0.214 0.786 1 9 5 14.000 14.000 0.002* 0.001* 16 MAOB.hCV8878790 14 9 5 0 0.643 0.357 6 2 6 14.000 14.000 0.001* 0.000* 17 TH.hCV243542 15 8 4 3 0.633 0.367 6 2 7 4.863 4.863 0.029* 0.034* 18 TH.hCV1843075 14 4 5 5 0.464 0.536 3 4 7 1.114 1.114 0.292 0.316 19 COMT.hCV11804650 14 4 2 8 0.571 0.429 5 3 7 0.389 0.389 0.625 1.000 20 COMT.hCV11804654 15 4 5 6 0.467 0.533 3 4 7 0.579 0.579 0.624 0.604 21 COMT.hCV2538746 15 2 5 8 0.400 0.600 2 5 7 0.185 0.185 1.000 1.000 22 COMT.hCV2538747 15 4 3 8 0.533 0.467 4 3 7 0.077 0.077 1.000 1.000 23 COMT.hCV2539306 15 4 3 8 0.533 0.467 4 3 7 0.077 0.077 1.000 1.000 24 COMT.hCV2539273 15 9 1 5 0.767 0.233 9 1 5 0.070 0.070 1.000 1.000 25 COMT.hCV3274705 12 9 0 3 0.875 0.125 9 0 3 0.245 0.245 1.000 1.000 26 POMC.hCV3227244 15 0 10 5 0.167 0.833 0 10 4 0.600 0.600 1.000 1.000 27 CRHR1.hCV2544843 15 3 6 6 0.400 0.600 2 5 7 0.417 0.417 0.620 0.600 28 CRHR1.CRHR1.7450777 15 0 10 5 0.167 0.833 0 10 4 0.600 0.600 1.000 1.000 29 CRHR1.hCV2544836 15 4 5 6 0.467 0.533 3 4 7 0.579 0.579 0.618 0.604 30 CRHR1.hCV2544830 14 2 5 7 0.393 0.607 2 5 7 0.032 0.032 1.000 1.000 31 CRHR1.hCV2257689 15 7 3 5 0.633 0.367 6 2 7 1.195 1.195 0.281 0.296 32 CRHR1.hCV1570087 15 6 3 6 0.600 0.400 5 2 7 0.417 0.417 0.625 0.600 33 CRHR2.hCV15872871 15 1 8 6 0.267 0.733 1 8 6 0.008 0.008 1.000 1.000 34 CRHR2.hCV11823513 15 2 7 6 0.333 0.667 2 7 7 0.150 0.150 1.000 0.616 35 CRHR2.hCV15960586 15 0 14 1 0.033 0.967 0 14 1 0.018 0.018 1.000 1.000 36 NR3C1.hCV11837659 15 3 9 3 0.300 0.700 1 7 6 4.116 4.116 0.105 0.058 37 NR3C1.hCV11159943 15 5 1 9 0.633 0.367 6 2 7 1.278 1.278 0.288 0.578 38 NR3C1.hCV8950988 14 3 8 3 0.321 0.679 1 6 6 3.624 3.624 0.084 0.072 39 NR3C1.hCV8950998 15 5 1 9 0.633 0.367 6 2 7 1.278 1.278 0.289 0.578 40 NR3C1.hCV1046361 15 9 2 4 0.733 0.267 8 1 6 1.519 1.519 0.512 0.226 41 NR3C1.hCV1046353 15 1 5 9 0.367 0.633 2 6 7 1.278 1.278 0.278 0.578 42 NR3C1.hCV1046360 14 3 2 9 0.536 0.464 4 3 7 1.196 1.196 0.291 0.589 * Null Hypothesis that Observed Values Match Hardy-Weinberg Equilibrium REJECTED at 0.05 level