Seth Noone: Research Technician
Project summary: Perfoming chromatin immunoprecipitations along with microarray analysis to elucidate cohesin association throughout S. cerevisiae's genome.
Email Seth: agides57@hotmail.com
Jill Henry: Research Technician
Project summary:
During meiosis, each chromosome must pair with its homolog and undergo meiotic crossover recombination
in order to segregate properly at the first meiotic division. Recombination in meiosis in Saccharomyces cerevisiae
relies on two Escherichia coli recA homologs, Rad51 and Dmc1, as well as the more recently discovered
heterodimer Mnd1/Hop2. Meiotic recombination in S. cerevisiae mnd1 and hop2 single mutants is initiated via
double-strand breaks (DSBs) but does not progress beyond this stage; heteroduplex DNA, joint molecules, and
crossovers are not detected. My work forcuses on Mnd1/Hop2, and our finding that it is required for DNA-DNA interactions that help ensure Dmc1-mediated stable strand invasion between homologous chromosomes, thereby preserving genomic integrity.