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Robb Krumlauf |
Regulatory pathways patterning the vertebrate brain and body plan in development, disease and evolution
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Our laboratory is interested in understanding the molecular and cellular pathways that govern patterning of the nervous system and body plan of vertebrate embryos during development; how they are altered or affected in human diseases; and how these pathways are conserved in evolution. One biological focus of the group is the hindbrain and its relationship to head development. This is a good model system for addressing fundamental patterning problems in neurobiology related to cell signaling, proliferation, migration, commitment, identity and differentiation. The hindbrain is a complex co-ordination center in the vertebrate CNS and an important source of patterning information that influences the generation of head and facial structures. It serves as a higher order relay center that controls respiration, blood pressure, arousal and wakefulness and it contains the nuclei and fibers of the cranial nerves, which innervate the muscles of the head and neck, transmit sensory information on hearing, balance and taste and control the cardiovascular and gastrointestinal systems.
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See also http://www.stowers-institute.org/labs/krumlauflab.asp |
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