LOCUS NM_001081049 16439 bp mRNA linear ROD 18-FEB-2007 DEFINITION Mus musculus myeloid/lymphoid or mixed-lineage leukemia 1 (Mll1), mRNA. ACCESSION NM_001081049 XM_110671 VERSION NM_001081049.1 GI:124486681 KEYWORDS . SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 16439) AUTHORS Dorrance,A.M., Liu,S., Yuan,W., Becknell,B., Arnoczky,K.J., Guimond,M., Strout,M.P., Feng,L., Nakamura,T., Yu,L., Rush,L.J., Weinstein,M., Leone,G., Wu,L., Ferketich,A., Whitman,S.P., Marcucci,G. and Caligiuri,M.A. TITLE Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations JOURNAL J. Clin. Invest. 116 (10), 2707-2716 (2006) PUBMED 16981007 REMARK GeneRIF: An in-frame partial tandem duplication of the MLL gene results in overexpression of hoxA proteins through increased histone modification within their promotors. REFERENCE 2 (bases 1 to 16439) AUTHORS Kong,C.T., Sham,M.H., So,C.W., Cheah,K.S., Chen,S.J. and Chan,L.C. TITLE The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice JOURNAL Leukemia 20 (10), 1829-1839 (2006) PUBMED 16888613 REMARK GeneRIF: Mll(Een/+) chimeric mice developed leukaemia displaying enlarged livers, spleens, thymuses and lymph nodes owing to infiltration of Mll(Een/+)-expressing leukemic cells REFERENCE 3 (bases 1 to 16439) AUTHORS Takeda,S., Chen,D.Y., Westergard,T.D., Fisher,J.K., Rubens,J.A., Sasagawa,S., Kan,J.T., Korsmeyer,S.J., Cheng,E.H. and Hsieh,J.J. TITLE Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression JOURNAL Genes Dev. 20 (17), 2397-2409 (2006) PUBMED 16951254 REMARK GeneRIF: Taspase1 is an endopeptidase that orchestrates cell cycle progression through site-specific proteolysis. REFERENCE 4 (bases 1 to 16439) AUTHORS Yamashita,M., Hirahara,K., Shinnakasu,R., Hosokawa,H., Norikane,S., Kimura,M.Y., Hasegawa,A. and Nakayama,T. TITLE Crucial role of MLL for the maintenance of memory T helper type 2 cell responses JOURNAL Immunity 24 (5), 611-622 (2006) PUBMED 16713978 REFERENCE 5 (bases 1 to 16439) AUTHORS Terranova,R., Agherbi,H., Boned,A., Meresse,S. and Djabali,M. TITLE Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (17), 6629-6634 (2006) PUBMED 16618927 REMARK GeneRIF: major function of Mll is to act at the chromatin level to sustain the expression of selected target Hox genes during embryonic development REFERENCE 6 (bases 1 to 16439) AUTHORS Yu,B.D., Hess,J.L., Horning,S.E., Brown,G.A. and Korsmeyer,S.J. TITLE Altered Hox expression and segmental identity in Mll-mutant mice JOURNAL Nature 378 (6556), 505-508 (1995) PUBMED 7477409 REFERENCE 7 (bases 1 to 16439) AUTHORS Ma,Q., Alder,H., Nelson,K.K., Chatterjee,D., Gu,Y., Nakamura,T., Canaani,E., Croce,C.M., Siracusa,L.D. and Buchberg,A.M. TITLE Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (13), 6350-6354 (1993) PUBMED 8327517 REFERENCE 8 (bases 1 to 16439) AUTHORS Gu,Y., Nakamura,T., Alder,H., Prasad,R., Canaani,O., Cimino,G., Croce,C.M. and Canaani,E. TITLE The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene JOURNAL Cell 71 (4), 701-708 (1992) PUBMED 1423625 REFERENCE 9 (bases 1 to 16439) AUTHORS Tkachuk,D.C., Kohler,S. and Cleary,M.L. TITLE Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias JOURNAL Cell 71 (4), 691-700 (1992) PUBMED 1423624 REFERENCE 10 (bases 1 to 16439) AUTHORS Djabali,M., Selleri,L., Parry,P., Bower,M., Young,B.D. and Evans,G.A. TITLE A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias JOURNAL Nat. Genet. 2 (2), 113-118 (1992) PUBMED 1303259 REMARK Erratum:[Nat Genet. 1993 Aug;4(4):431. PMID: 8401594] COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC061963.13 and AC142113.2. On Feb 6, 2007 this sequence version replaced gi:94386072. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. FEATURES Location/Qualifiers source 1..16439 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="9" /map="9 26.0 cM" gene 1..16439 /gene="Mll1" /note="myeloid/lymphoid or mixed-lineage leukemia 1; synonyms: HRX, Mll, All1, ALL-1, Cxxc7, HTRX1, KIAA4050, mKIAA4050, 6430520K01" /db_xref="GeneID:214162" /db_xref="MGI:96995" CDS 1..11892 /gene="Mll1" /GO_component="nuclear part; nucleus" /GO_function="DNA binding; metal ion binding; protein binding; zinc ion binding" /GO_process="anterior/posterior pattern formation; DNA methylation; embryonic hemopoiesis; regulation of histone H3-K4 methylation; regulation of transcription, DNA-dependent; transcription" /note="trithorax Drosophila" /codon_start=1 /product="myeloid/lymphoid or mixed-lineage leukemia 1" /protein_id="NP_001074518.1" /db_xref="GI:124486682" /db_xref="GeneID:214162" /db_xref="MGI:96995" /translation="MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGP QAGGGGPGAPPSPPAVAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPA LLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSP TRSPSVKASPRKPRGRPRSGSDRNPAILSDPSVFSPLNKSETKSADKIKKKDSKSIEK KRGRPPTFPGVKIKITHGKDIAELTQGSKEDSLKKVKRTPSAMFQQATKIKKLRAGKL SPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEG TPPLTKEDKTVVRQSPRRIKPVRIIPSCKRTDATIAKQLLQRAKKGAQKKIEKEAAQL QGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPMKIARLESTPNSRFS ATSCGSSEKSSAASQHSSQMSSDSSRSSSPSIDTTSDSQASEEIQALPEERSNTPEVH TPLPISQSPENESNDRRSRRYSMSERSFGSRATKKLPTLQSAPQQQTSSSPPPPLLTP PPPLQPASGISDHTPWLMPPTIPLASPFLPASAAPMQGKRKSILREPTFRWTSLKHSR SEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHS GTRFDIHKRSPILRAPRFTPSEAHSRIFESVTLPSNRTSSGASSSGVSNRKRKRKVFS PIRSEPRSPSHSMRTRSGRLSTSELSPLTPPSSVSSSLSIPVSPLAASALNPTFTFPS HSLTQSGESTEKNQRARKQTSALAEPFSSNSPALFPWFTPGSQTEKGRKKDTAPEELS KDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSDIQSSSALYPVGRVSKEKVA GEDVGTSSSAKKATGRKKSSSLDSGADVAPVTLGDTTAVKAKILIKKGRGNLEKNNLD LGPAAPSLEKERTPCLSAPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQ LCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMP TLSALPWEEREKILSSMGNDDKSSVAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKG RRSRRCGQCPGCQVPEDCGICTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKASLQ KQTKAVKKKEKKSKTTEKKESKESTAVKSPLEPAQKAAPPPREEPAPKKSSSEPPPRK PVEEKSEEGGAPAPAPAPEPKQVSAPASRKSSKQVSQPAAVVPPQPPSTAPQKKEAPK AVPSEPKKKQPPPPEPGPEQSKQKKVAPRPSIPVKQKPKDKEKPPPVSKQENAGTLNI LNPLSNGISSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLC ASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQL LECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDF SLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSDEMYEILS NLPESVAYTCVNCTERHPAEWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAKP PDLNPETEESIPSRSSPEGPDPPVLTEVSKQDEQQPLDLEGVKKRMDQGSYVSVLEFS DDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSNN SGMLPNAVLPPSLDHNYAQWQEREESSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHP PTPPILSTDRSREDSPELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHV NCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCS RAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPE NIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIMECR PPVVEPDINSTVEHDDNRTIAHSPSSFIDASCKDSQSTAAILSPPSPDRPHSQTSGSC YYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGS RRHSTSSLSPLRSKLRIMSPVRTGSAYSRSSVSSVPSLGTATDPEASAKASDRGGLLS SSANLGHSAPPSSSSQRTVGGSKTSHLDGSSPSEVKRCSASDLVPKGSLVKGEKNRTS SSKSTDGSAHSTAYPGIPKLTPQVHNATPGELNISKIGSFAEPSTVPFSSKDTVSYPQ LHLRGQRSDRDQHMDPSQSVKPSPNEDGEIKTLKLPGMGHRPSILHEHIGSSSRDRRQ KGKKSSKETCKEKHSSKSYLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSE KIGDKVLPLSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMEGENQSKNTQKESGPG SPAHIESVCPAEPVSASRSPGAGPGVQPSPNNTLSQDPQSNNYQNLPEQDRNLMIPDG PKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSA EGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDG VDDGTESDTSVTATSRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVIKSAVGHKNE PKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNAELLKSDSDN NNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLTLGEGLGLDSNREKDIGL FEVFSQQLPATEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAV ISDSGEKRVTITEKSVASSEGDPALLSPGVDPAPEGHMTPDHFIQGHMDADHISSPPC GSVEQGHGNSQDLTRNSGTPGLQVPVSPTVPVQNQKYVPSSTDSPGPSQISNAAVQTT PPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPSVMETNTSVLGPM GSGLTLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPPNISSPPSG LLIGVQPPPDPQLLGSEANQRTDLTTTVATPSSGLKKRPISRLHTRKNKKLAPSSAPS NIAPSDVVSNMTLINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQA PLLPPQSVGGTAATAAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTAAPTSST SVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPPSSGMFPQLGTSQT PSAAAMTAASSICVLPSSQTAGMTAASPPGEAEEHYKLQRGNQLLAGKTGTLTSQRDR DPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPSAKPASSASPGSSPSSGQQSGSSSVP GPTKPKPKAKRIQLPLDKGSGKKHKVSHLRTSSEAHIPHRDTDPAPQPSVTRTPRANR EQQDAAGVEQPSQKECGQPAGPVAALPEVQATQNPANEQENAEPKAMEEEESGFSSPL MLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNA RLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKPEEANEPPLNPHG SARAEVHLRQSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRF RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSK GIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYR GEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN" unsure 99..106 /gene="Mll1" /note="<30 qual SNGL region" unsure 133..147 /gene="Mll1" /note="<30 qual SNGL region" STS 1335..2175 /gene="Mll1" /standard_name="PMC27946P1" /db_xref="UniSTS:272393" STS 3584..3893 /gene="Mll1" /standard_name="Mll1" /db_xref="UniSTS:143875" STS 4310..5388 /gene="Mll1" /standard_name="Mll" /db_xref="UniSTS:143874" STS 9221..9636 /gene="Mll1" /standard_name="MARC_12741-12742:1029349377:1" /db_xref="UniSTS:267437" STS 12466..12664 /gene="Mll1" /standard_name="L17069" /db_xref="UniSTS:124876" ORIGIN 1 atggcgcaca gctgtcggtg gcgcttcccc gcccgacccg ggaccaccgg gggcggcggc 61 ggcggggggc gccggggcct agggggcgcc ccgcggcaac gcgtcccggc cttgctgctt 121 ccccccgggc cccaggccgg cggtggcggc cccggggcgc ccccctcccc cccggcggtg 181 gcggcggcgg cggcgggaag cagcggggct ggggttccag ggggagcggc cgccgcctca 241 gcagcctctt cgtcgtccgc ctcgtcttcg tcttcgtcat cgtcctcagc ctcctcaggg 301 ccggccctgc tccgggtggg cccgggcttc gacgcggcgc tgcaggtctc ggccgccatc 361 ggcaccaacc tgcgccggtt ccgggcagtg tttggggaga gcggcggggg aggcggcagc 421 ggagaggatg agcagttctt aggttttggc tcagatgaag aagtcagagt gcgaagcccc 481 accaggtctc cttcagttaa agctagtcct cgaaaacctc gcgggagacc tagaagtggc 541 tctgaccgga acccagccat cctctcagac ccatctgtgt tttcccctct aaacaaatca 601 gagaccaaat ctgcagataa aatcaagaag aaagattcta agagcataga aaagaagaga 661 ggaagacctc ctaccttccc tggggtaaaa atcaaaatca cacatggaaa ggacattgca 721 gagttaacac aaggaagcaa agaggatagc ctgaaaaaag ttaaacggac cccttctgcc 781 atgttccagc aagccacaaa gattaaaaag ttaagagcag gtaaactgtc tcctctcaag 841 tctaagttta agacagggaa gctccaaata ggaaggaagg gggtgcagat tgtaagacgg 901 cgaggaaggc ctccatccac agaacggata aagacccctt caggtcttct cattaattct 961 gaactggaaa agcctcagaa ggtccggaaa gacaaggaag gaacaccccc tctcacaaaa 1021 gaagataaga cagttgtcag acaaagccct cgaaggatta aaccggtcag gattattcct 1081 tcttgtaaaa ggacagatgc cacaattgct aagcaactcc tgcagagggc aaagaagggg 1141 gcgcagaaga aaattgagaa agaagcggct cagctgcagg gaaggaaggt gaagacgcag 1201 gtcaagaata tccggcagtt catcatgcct gtggtcagcg ccatctcctc gaggatcatc 1261 aagactcccc ggcggttcat agaggatgag gattatgacc cacccatgaa gattgcacgc 1321 ctggaatcta ccccgaacag cagattcagc gccacgtcct gtggatcctc ggagaagtcc 1381 agtgccgcct cccagcactc ctctcagatg tcttcagact cctcccgatc cagcagcccc 1441 agtatcgata ccacctcaga ttctcaggcc tctgaagaga tccaggcact tcccgaggag 1501 cgcagtaata cccccgaagt tcatactcca ctgcctattt cccagtcccc agaaaatgag 1561 agtaatgata ggagaagcag acggtattcg atgtctgaga gaagctttgg atctagagca 1621 actaaaaaat taccaactct acaaagtgcc ccccagcagc agacctcctc ctcgccacct 1681 ccgcctctgc tcacccctcc ccctccactg cagccagcct ccggcatctc tgaccacaca 1741 ccttggctta tgcctcccac catcccttta gcatcaccat tcctgcctgc ttctgctgct 1801 cccatgcaag ggaagcggaa atctattttg cgggagccaa catttaggtg gacttcttta 1861 aaacattcga ggtcagagcc acagtacttt tcctcagcaa agtatgccaa agaaggtctg 1921 attcgcaaac caatatttga taacttccga ccccctccgc tgactcccga ggatgtcggc 1981 tttgcttctg gtttttctgc atctggtact gccgcttcgg cccggttgtt ttcaccactc 2041 cattctggaa caaggtttga tattcataaa aggagcccca ttctgagagc tcccagattt 2101 actccaagtg aggcacactc tagaatattt gagtctgtga ccttgcctag taatcgaact 2161 tcttctggag cgtcctcttc gggagtatct aatagaaaaa ggaaaaggaa agtgtttagt 2221 ccgattcggt ctgaaccaag atcaccttct cactccatga ggacaagaag cggaaggctt 2281 agcacctctg agctgtcacc tctcactccc ccgtcttctg tctcctcctc attaagcatt 2341 cccgttagtc ctcttgccgc tagtgcctta aacccaactt ttacttttcc ttctcattcc 2401 ctaactcagt ctggggaatc tacagaaaaa aatcagagag caaggaagca gactagtgct 2461 ctggcagagc cattctcgtc aaatagccct gctctcttcc catggttcac cccaggctct 2521 cagaccgaga aggggagaaa gaaagacaca gccccggagg agctgtccaa agatcgcgat 2581 gctgacaaga gcgtggagaa ggacaagagt agagagagag accgggagcg agagaaggag 2641 aataagcggg aatcaaggaa agagaaaagg aaaaagggct cagacattca gagtagctct 2701 gctttgtatc ctgtgggtcg ggtttccaaa gagaaggttg ctggagaaga tgttggcact 2761 tcatcttctg ccaaaaaagc aacagggcgg aagaagtctt cgtcacttga ttctggggct 2821 gatgttgctc ctgtgactct tggggacaca acagctgtca aagccaaaat tcttataaag 2881 aaagggagag gaaatctgga aaaaaacaac ttggacctcg gcccagctgc cccgtccctg 2941 gagaaggaga gaaccccctg cctttccgct ccttcatcta gcactgttaa acactccact 3001 tcctccatag gctccatgtt ggctcaggca gacaagcttc caatgactga caagagggtt 3061 gccagcctcc taaaaaaggc caaagcccag ctctgcaaga ttgagaagag taagagtctc 3121 aaacagactg accagcccaa agcacagggt caagaaagtg attcatcaga aacctctgtt 3181 cgaggacccc ggattaaaca tgtctgcaga agagctgctg ttgcccttgg ccgcaaacga 3241 gctgtgtttc ctgatgacat gcccaccttg agtgccttac cgtgggaaga acgagaaaaa 3301 attttgtctt ccatggggaa tgatgacaag tcatcagttg ctggctcaga agatgccgag 3361 cctcttgctc ctcccatcaa accaattaag cctgtcacca gaaacaaggc acctcaggag 3421 cctccggtga agaaagggcg gcgatcaagg cggtgcggac aatgtcctgg ctgccaggtg 3481 cctgaggact gtggcatttg cactaattgc ctggacaagc ccaagtttgg tggccgcaat 3541 ataaagaagc aatgctgcaa gatgaggaaa tgtcagaatc tgcagtggat gccttccaaa 3601 gcctcccttc agaagcagac taaagctgtg aaaaagaaag agaaaaagtc taagaccact 3661 gaaaagaaag agagcaaaga gagcactgct gtgaagagcc ccttggagcc tgctcagaag 3721 gctgccccgc caccgcggga ggagcctgcc ccaaagaaga gcagcagtga gcctccaccc 3781 cgcaaacctg tggaagaaaa gagtgaagaa gggggtgccc ctgcgcctgc ccctgcgcct 3841 gaacccaaac aggtcagcgc gccagcatcc cggaagtcca gcaagcaggt ctcccagcca 3901 gcagccgtcg tcccccctca gcctcctagc acagcaccgc agaaaaaaga agctcccaag 3961 gccgttccaa gtgagcccaa gaaaaagcaa cctccacccc cagaaccagg gccagagcaa 4021 agcaagcaga aaaaagtggc cccccgccca agtatccctg taaaacaaaa accaaaggac 4081 aaggagaagc cacctccagt aagtaaacaa gagaatgcag gcactttgaa catcctcaac 4141 ccactctcga atggcatcag ttctaagcag aaaatcccag cagatggagt ccacaggatc 4201 agagtggact ttaaggaaga ctgtgaagca gaaaatgtgt gggagatggg aggcttaggg 4261 atcctgacct ctgtccccat aacacccaga gtagtgtgct ttctctgtgc cagcagtggg 4321 catgtagagt ttgtgtattg ccaagtgtgt tgtgaaccct tccacaagtt ttgcttagag 4381 gagaatgagc gccccctgga ggaccagctg gaaaactggt gttgtcgccg ctgcaagttt 4441 tgccatgtgt gtggaagaca gcatcaggct acaaagcagt tgctggagtg taacaagtgc 4501 cgaaacagct atcaccccga gtgcctggga ccaaactacc ccaccaaacc cacgaagaaa 4561 aagaaagtgt ggatctgcac caagtgtgtc cgctgcaaga gctgtggctc caccactcca 4621 ggcaaagggt gggacgcaca gtggtctcac gatttctcac tgtgccatga ctgtgccaaa 4681 ctctttgcta aagggaactt ctgccctctc tgtgacaagt gctacgatga cgatgactac 4741 gagagcaaga tgatgcagtg cgggaagtgt gaccgctggg tccactccaa gtgcgagagt 4801 ctctcagatg agatgtatga gattctgtcc aacttgccag aaagtgtggc ctacacgtgt 4861 gtgaactgca ctgagcggca ccccgcagag tggagactgg ccctggagaa ggagctgcag 4921 gcgtccctca agcaggttct cacggccctg ttgaattctc ggactaccag tcacttgctg 4981 cgctaccgtc aggctgccaa gcctccagac ttaaaccctg agactgagga aagcatacct 5041 tcccgaagct ccccagaggg gccagaccct cctgttctta ctgaggtcag caagcaggat 5101 gaacagcagc cgttagacct cgaaggggtc aagaagagaa tggaccaggg cagctacgta 5161 tctgtgttgg agttcagcga tgatattgtg aagatcattc aggcagccat taactcagat 5221 ggagggcagc cagagataaa aaaagccaac agcatggtca agtctttctt cattcggcaa 5281 atggagcgag tttttccgtg gttcagtgtc aaaaagtcta gattttggga gccaaataaa 5341 gtatcaaaca acagtgggat gttaccaaac gcagtgcttc cgccttcact tgaccataat 5401 tatgctcagt ggcaggagcg agaggagagc agccacactg agcagcctcc tctaatgaag 5461 aaaatcattc cagctcccaa acccaaagga cccggagagc cagactcgcc cacgccgctc 5521 cacccgccta cacccccgat cttgagtact gatcggagtc gagaagacag tccagagctg 5581 aatccacccc caggcatcga tgacaaccga cagtgtgcac tgtgtctgat gtacggcgat 5641 gacagtgcta atgatgctgg ccgtttgctg tacattggcc aaaatgagtg gacacatgtg 5701 aactgtgctt tgtggtcagc agaagtgttt gaagatgatg acggatcact gaagaatgtg 5761 catatggctg tgattagggg caagcagctg agatgtgaat tctgccagaa gccaggagcc 5821 accgtgggtt gctgcctcac atcttgcacc agcaactacc atttcatgtg ttcccgggcc 5881 aagaactgtg tcttcctgga tgataaaaaa gtgtattgtc agcggcatcg ggatttgatc 5941 aaaggcgagg tggttcctga gaatggattt gaagttttta gaagagtgtt tgtagatttt 6001 gaaggaatca gcttgcgcag gaagttcctt aatggcttgg aaccagaaaa tatccacatg 6061 atgataggct caatgacaat cgactgtttg ggaatcctga atgacctctc tgactgtgaa 6121 gataaactct ttcctattgg ataccagtgt tctcgggtgt actggagcac cacagatgcc 6181 cggaagcgct gtgtgtacac atgcaagatc atggagtgcc gccctcctgt tgtagagccg 6241 gatatcaaca gcacggttga gcacgatgac aataggacca ttgcccatag cccatcatca 6301 tttatagatg catcgtgtaa ggacagtcaa agcacagctg caattctcag tcctccgtcg 6361 ccagatcggc ctcattcaca gacctcaggc tcctgttatt atcatgtcat ctcgaaggtc 6421 cctaggattc gaacacccag ctactcgcct acacagaggt cccctggctg ccgcccattg 6481 ccttctgcag gaagtcctac cccaaccact cacgaaatcg tcacagtcgg tgacccgtta 6541 ctgtcttctg gtcttcggag cattggctct aggcgtcaca gtacttcttc cttgtcaccc 6601 ctgcggtcca agctccgcat aatgtctcca gtgagaacgg ggagcgctta ctccaggagt 6661 agtgtttcct cagtccccag ccttgggact gccacagatc ctgaggccag tgccaaagca 6721 tcggatcgag gagggctgtt gagttcaagt gctaatctcg ggcacagcgc tcccccctct 6781 tcaagctcac agaggacagt tggaggctcc aaaaccagtc atctggatgg gtcgtcaccc 6841 tcggaagtga agcggtgtag tgcttcagac ttggtaccca aaggctcctt agtaaaggga 6901 gagaaaaaca gaacttcaag ttccaagagc acagatggat ctgcacatag cacagcttac 6961 cctggaatcc ctaaactgac accacaggtt cataacgcaa ctcctggaga actaaacatt 7021 agcaaaattg gcagttttgc tgaaccctct acagtgccct tttcttctaa ggatacagtg 7081 tcctacccac agctccactt gaggggccaa agaagtgaca gagaccagca catggatcct 7141 tcccagtcag taaagccctc tccaaatgaa gatggtgaaa tcaaaacctt gaagctccct 7201 ggtatgggcc acaggccatc cattctacat gaacacatag ggtctagttc tagagacagg 7261 agacagaaag ggaaaaagtc ttctaaagag acttgcaaag aaaagcattc cagtaaatcc 7321 tacttggaac ctggccaggt gacaaccggt gaggaaggaa acctaaagcc agagtttgct 7381 gatgaggtgt tgactcctgg gtttcttggg caacgaccat gtaataatgt ttcatctgag 7441 aagattggag ataaagtcct tcctctttca ggagtcccta aaggtcaatc cacacaagtg 7501 gaaggatctt ccaaggagtt acaggcaccc cggaagtgct cggtcaaagt gacacctctg 7561 aagatggaag gtgagaatca atccaaaaac acccagaaag agagtggccc tggctccccc 7621 gcacacatag agtcagtgtg cccagcagag ccagtctcag cctccagaag cccaggagct 7681 ggcccaggag ttcagccgag ccccaacaat accttatccc aagatcctca aagtaacaac 7741 taccagaatc ttccagaaca ggacagaaac ctgatgattc cagatggccc caagcctcag 7801 gaggatggct cttttaaaag gcggtacccc cggcgcagtg cccgcgcacg gtctaacatg 7861 ttctttgggc tcaccccact gtatggagtc aggtcttacg gtgaagaaga cattccgttc 7921 tacagcaatt ccactgggaa aaagcgagga aagagatcag cagaaggcca ggtagatggg 7981 gccgacgacc tgagcacttc cgacgaagat gacttatact attacaactt cacgcggact 8041 gtgatttcct cgggtggaga ggagcggctg gcctcccata atttatttcg ggaggaagaa 8101 caatgtgatc ttccaaaaat ttcacagctg gatggtgtgg atgatgggac agagagtgac 8161 accagtgtca ctgccacaag caggaaaagc agccagattc caaagagaaa tggcaaagaa 8221 aatggaacag aaaacttaaa gattgatcga cctgaagatg ctggcgagaa agagcatgtc 8281 attaagagtg ctgttggcca caaaaacgag ccaaagctgg ataactgcca ctctgtaagc 8341 agagtgaaag cacagggcca ggattccttg gaagctcagc tcagctccct ggaatcgagc 8401 cgcagagtcc acacaagcac cccctcagac aaaaacttac tggatactta caacgctgag 8461 ctgctgaagt cagactctga caataacaac agtgatgact gtgggaacat cctgccttca 8521 gatatcatgg actttgtact aaagaatact ccatctatgc aggccctggg tgagagcccg 8581 gagtcgtcct cctctgagct cttgactctt ggtgaaggac tgggtcttga cagtaatagg 8641 gaaaaggata taggtctttt tgaagtgttt tctcagcaac tgccagcgac agagcctgtg 8701 gacagtagtg tctcctcttc catctcagca gaggagcagt ttgagctgcc tcttgagctg 8761 ccatctgacc tctctgtcct gaccacccgc agccccactg tccccagcca gaatcccagc 8821 agactggccg taatctcaga ttcaggggag aagcgagtga ccatcacaga aaaatcagta 8881 gcctcttccg agggtgaccc agccctgctg agtccaggag tagaccctgc tcctgaaggc 8941 cacatgacac ccgatcattt catccaagga cacatggatg cagaccatat ctccagccct 9001 ccctgtggct ccgtggaaca aggccatggc aacagtcagg atttaactag aaacagtggc 9061 actcctggcc ttcaggtacc tgtttccccc actgttcccg tccagaacca gaagtatgtg 9121 cccagttcca ctgacagccc tggcccatct cagatctcta acgcagctgt ccagaccact 9181 ccaccccacc tgaaaccagc cactgagaaa ctcattgttg ttaatcagaa catgcagcca 9241 ctttatgttc tccagactct tccaaatgga gtgacccaaa aaatccagtt gacctctcct 9301 gttagttcta cacccagtgt gatggagaca aatacctcgg tattggggcc catgggaagt 9361 gggctcaccc tgaccacagg actaaaccca agcttgccac cctctccgtc tctgttccct 9421 cctgctagca aaggattgct ctctgtgcct caccaccagc acctacattc cttccccgca 9481 gctgctcaaa gtagtttccc tcccaacatc agcagtcctc cttcaggcct gctcattggg 9541 gtccagcctc ctcccgatcc ccaacttctg ggttcagaag ccaaccagag gacagacctc 9601 actactacag tggccactcc atcctctgga ctcaagaaaa gacccatatc tcgtctgcac 9661 actcgaaaga ataaaaaact tgctccctct agtgcccctt caaatattgc cccttctgat 9721 gtggtttcta acatgacgct gattaacttc acaccctccc agctttcaaa ccaccccagt 9781 ctgttagact tggggtcact taacccttca tctcaccgaa ctgtccccaa catcataaaa 9841 agatctaaat ctggcatcat gtattttgaa caggcacccc tgttaccacc acagagtgtg 9901 ggcggaaccg ctgccacagc agcgggctca tcaacgataa gccaggatac tagccacctg 9961 acatctgggc ctgtgtctgc cttggcatcc ggttcgtccg tcctgaatgt ggtatccatg 10021 caaactacag cagcccctac aagtagcaca tcagttccag gtcatgtcac cttagccaac 10081 cagaggttgc ttgggacccc agatattggc tcaataagcc atcttctaat caaagccagc 10141 caccagagcc tgggcattca ggaccagcct gtggctttac caccaagttc aggaatgttc 10201 ccccagctgg ggacatcaca gactccctct gctgctgcaa tgacagcagc atctagtatc 10261 tgtgtgctcc cctcttctca gactgcaggc atgacagctg catcccctcc tggggaggcc 10321 gaagaacact ataagctaca gcgaggaaac cagctcctag ctggcaaaac cggtaccctg 10381 acttcacagc gggaccggga tcccgattct gctccgggga cccagccgtc caacttcacc 10441 cagacagcag aagctcctaa cggtgtgagg ctggagcaaa acaagacttt accctcagct 10501 aagccagcca gctccgcctc tccagggagc tccccatcct ctggacagca gtcaggaagt 10561 tcctcagtgc caggtcccac taaaccaaaa ccaaaagcca aacggattca gctgccccta 10621 gacaagggga gcggcaagaa gcacaaagtt tcccatttgc ggaccagttc tgaagcacac 10681 attccacacc gagacaccga ccccgcaccc cagccctcag tgacacggac tcctagagcg 10741 aacagggagc agcaggatgc agctggagtg gagcagccat cgcagaagga gtgtgggcag 10801 ccggcaggac cagtggctgc tcttccagag gtccaggcaa cacagaatcc agccaatgag 10861 caagaaaatg cagaacctaa agcaatggaa gaagaagaga gtggtttcag ctctcctctg 10921 atgctctggc tccagcaaga acaaaagagg aaagaaagca ttactgagag gaagcccaag 10981 aaaggactcg tttttgaaat ttcaagtgat gatggctttc agatctgtgc ggaaagtatt 11041 gaagatgcct ggaagtcact gacagataaa gtccaggagg cacgatcaaa tgcccgcctg 11101 aagcagctct catttgcagg tgtgaacggt ttgcggatgc tggggattct ccatgatgcc 11161 gttgtgtttc tgattgagca gctggctggg gccaagcact gtcggaatta caaattccgt 11221 ttccacaaac cagaagaggc caacgaaccc cccttgaacc ctcacggctc agccagggct 11281 gaggtccacc taaggcaatc agcatttgac atgtttaact tcctggcttc taaacatcga 11341 cagccccctg agtacaaccc taacgatgag gaagaggaag aggtccagct gaaatccgca 11401 cggagggcaa caagcatgga tctcccaatg cccatgagat tccggcactt gaagaagact 11461 tctaaggagg cggttggtgt ctacaggtct cccatccatg gtcggggtct tttctgtaag 11521 agaaacatcg atgcaggaga gatggtgatt gaatacgccg gcaacgtcat ccgctccatc 11581 cagacagaca agcgtgagaa gtactatgac agcaagggca ttggttgcta catgttccga 11641 attgatgact cggaggtagt ggatgccacc atgcatggaa atgctgcacg cttcatcaat 11701 cactcttgtg agcctaactg ctactcccgg gtcatcaata ttgatgggca gaagcacatt 11761 gtcatcttcg ccatgcgtaa gatctaccgg ggggaggagc tcacctatga ctataagttc 11821 cccattgagg acgccagcaa caagctaccc tgcaactgtg gcgccaaaaa atgccgcaag 11881 ttcctgaact aaagctgttc atcttcctgt gatggagaac caggacccag ggccacccaa 11941 agccatgctg aaggacttcc cagcacccaa gagctccaag gattgagcag gcagttgagg 12001 gtcctctggc tggtccctag tgtcctacat atacatcatg tgatcatagt cttggagaga 12061 gaagggtctc aaagaaaaga tccccagatg gctttcccct gggccctctt tgattgttga 12121 aaaacctgag aaactggttc ctgggagaat ttgcctgcaa ggagcatgta gagggttcct 12181 tacagtgggt ctgagcatgt cctcagagag cagtttgtca tcctcatctt agccctctcc 12241 ctaaaaacga tgggtcagac aagaccccag atacagggtt ggtgagatac ctggtagttt 12301 gccagttagg ccagtcctgt ggccatctgt tgaacaaaca aatgacctag tggttttccc 12361 tactatctgc ccacttaaga gttcactttg gttgggagac aggtttccta gcacctccgg 12421 tgtcaaaagg ctgtcttggg gttgtgccaa ttaattacca aacattgagc ctgtggctgt 12481 aagtgggagt gttaccctgt gagccttacc gtagccagtg acctttcttg acgataggag 12541 cggctccctc tccatccctt ctctttactc cctcctcccc tcctccatcc ttcatctgct 12601 gctttcccat tctttctggg tagcgggagc ttgcctccct gctcaagggc actccctact 12661 tggtatagga agtgcctaca gaaagtcccc caagccagta agcactccag gtggggaatt 12721 ggacagaagc cgttggccgt aaccagacgg aatttggaga tctcataaag ctccattgag 12781 agttttaaag agatgtatgt agcgaggttt ttttaaacaa gagactaaag attatttaaa 12841 taggatttga gtcatgcagc agcctgagtc catagccagg atatgcccat ccccttccca 12901 ggacgtgctt actctctttc ccctttctga agacatagga agatgagttt ctaaaaggtc 12961 agggtccagc tgaaagaaca ctaatcagat ttcaaggccc caaacttggg ggactagacc 13021 acatgtgcta agggacctct gccacccgtg tgcagcctgt ggctgagcaa gttcaatgac 13081 actactgccc tggttactcc ttagggtgtg gacagccagc agcaaatgtt tctttcttcc 13141 cccaagacag agtcttgaac ctgttagatt aagtcattgg attttcctct gttctgttta 13201 cagtttacta tttaaggttt tataatgtaa atatattttg tatatttttc tatttgaagc 13261 acttcatagg gagaagcact tatgacgagg ctatttttaa accgcggtat tatcctaatt 13321 taaaagaaga tcggttttta atgatttttt attttcatag gatgaagtga gagaaaatat 13381 tcagctgtcc acacaaagtc tggtttccct gcccagcttc cccctggaaa gtgtactttt 13441 tgttgttcca tgtgtagctc gtttgtgccc attgacataa atgttccttg ggtctgctct 13501 ttatagtaac tgaaaaagaa ggtcacccac tccattaggc cactgccctc cagggccaag 13561 gactgagggt acagaacctt agcacaccag tgtctcctcc tctttgctgt attgccccct 13621 ccctctggat cagccccaga gtgggaagca gcaggctccg tttcgctccc ctttctcttt 13681 ctgagttagc aaccaagaag ctgcaacttg acattcgcca tcacatctgc ctcatccatc 13741 acctcctttc cttctctgcc caccaagtcc ttgtacccgc agagaaccca ctgaccgcct 13801 cctgccctct cggggcagat tgttgaacct gaagcacagt atgaccactc acgatcaagc 13861 agatctctgc gcctgccaca aggtttcagg gtagcgtagt ccgagtggag ggcagggcac 13921 cctttctctt atggaagtca gcaaagcaat atgatgcagc ccagaactct ctgccaggac 13981 tcgtggctct gctgtgcctt ccatcctggg ctcctttcct tctgtgacct taagaacttt 14041 gtctggtggc tttgctggaa cattgtcact gtttccactg tgggaagccc agcactgtgg 14101 ccaggatggc agagatttcc ttgtcatcat ggagaagtgc cagcagggga ctggggaaaa 14161 gcactctacc cagacctcac ctcctaccct cctttgccca tgaacaagac gcagtggccc 14221 aaggggtttc actagtgtct ggtttccttc ttattgcact gtgtgaggtt tttttgtaaa 14281 tccttgtatt cctaattttt ttttatgaaa aaatgtaagc tgcatttgtt actgaaagat 14341 taaatgcact gatgggtcat gcgttcatcc tgagagaccc aaaggccagt cagagggtgg 14401 ggggaactca gctaacagac ctagtcactg ccctgctagg ccatgctgta ctgtgagccc 14461 cctcctcatc ctcttcctac aaccccaatc cctgaggacg gggggaaccc acctttcctc 14521 ctcctccagc tggtttgcct tgccctccca ctcactgtca accacagaaa cgagaaattc 14581 ctctttcagc tcagccttga gtccattgcc aaaattcagc atacctgcca gcaacttggg 14641 ggataagcca gagtatcccc acaagcggga gagaaggcaa caaaacagaa ggcacagctg 14701 tctccaaaac acatctgctt tgttttgaaa gtgaccaaga gaacctccgc acaaaagtgc 14761 aggttgagga ctttgcgctg ggtcattccc aagaatcccc caaggggcaa cccaccgcct 14821 caggagtgac agctgcggac ctcgagggtt ccggctttgc tgctagaacc tgttgtggct 14881 gcgtttcctg gtggcagtga caactgtgta accagaatag ctgcatggcg ctgacccttt 14941 ggtcggaact tggtccctgg gctccctcag tgctgcccat gtccagcaca acccctccct 15001 gtttttaaac caatcacaat taaggaggaa gccctggcac ttcttaggtt ttcaacccaa 15061 actccttttt caggacccag ctcacctctg tcaaaccccg gccaatccaa taagcaccat 15121 gcagcaacct tgatttaaaa aaagaagaaa agaagaaaaa aaaaaaactt aaaataaaat 15181 aaaataaaaa aatacaacac acatacacaa aaaaatcttt taatgaatgt atctttctaa 15241 aggactgacg ctcaatcaaa tacctgaaaa tactagaggt cacagcctca tctgatgtta 15301 acttttattg gatttgggat tctttttcat agaaaccaag ttgttttttg ttgttattgt 15361 tgttgttgtt gttgttgttt tttaaggaaa agcgggtcat tgcaaagggc tgggtgtaat 15421 tttacgtttc ctttccttca ttttaaagca atacaaagtt attgaacaga tagttttgtg 15481 ccgaatcatg aataccagtc aagtctcaca ctctgaaaac ttgcaacctt tttgtttgtt 15541 tgttttggtt ttcaaataaa tataaatata tatatatata ggaactaata taggaatgca 15601 ccattgtaac aaagcctagt tcagtccatg gcttttactt ctcttaacac tatagataag 15661 gattgtgcta cagttgctag tggggcaggg aaatgtcagg ctcccagtga cagtgacggt 15721 ggtgctgact ccacatacgg atgacagacg cccgcctgtc ccgagaggag cgtgcagagc 15781 agatctgctc tcacctggct tcttcctgcc tgtggacgtt gccagtcggt acctgtactc 15841 ctcgtctact tccggttatg aatgttgggg tcaccacctg catctagggg aaaattgtgt 15901 tctgtgcttt ctggtatctt gttctggggt acactagttc tgtctttcaa ccaagaaaaa 15961 aaaatagatt tgtggtgttt cttttcttga actttaacag tctccttagc aaatacaggt 16021 agttgaataa ttgtttcatg agctgaacag tggcaagctt catttctaga ataagacatt 16081 tctctacagc tgtgtcatgt acaatggatc ttttgggggt tttttgtttg ttttgtttgc 16141 ttcccttttt ttccttgtgt tcttccaagc ttctggttag agacaaagtg ggggggggga 16201 aggaaaacgt gtctgaagcc catcagtgtt aactccctga gacagggatg aaggaaaata 16261 ctttaatatt caaaaaataa taatgctgaa agctctctac gaaagactga atgtaaaagt 16321 aaaaagtgta catagttgta aaaacaaaaa aaggagtttt taaacatgtt tattttctat 16381 gcactttttt ttatttaagt gatagtttaa ttaataaaca tgtcaagttt attgctgca //