The Stowers Institute For Medical Research

"Ben" Sheng Xia

shx@stowers-institute.org

WORK EXPERIENCE

Assistant Lecturer, Molecular Biology course and Gene Engineering course for undergraduate students, School of Life Science and Technology, Huazhong University of Science and Technology (1998-2001).

Lecturer, Molecular Biology Course and Gene Engineering Course for Undergraduate students, School of Life Science and Technology, Huazhong University of Science and Technology (2001- 2005).

Guest researcher, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (2002.2-2003.5).  Sponsored by IBRO (International Brain Research Organization) fellowship.

Post doctor, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (2003.12-2005.9).  Sponsored by EMBO (European Molecular Biology Organization) fellowship and STINT (Swedish Foundation for International Cooperation in Research and Higher education) fellowship.

Postdoctoral Research Associate, Stowers Institute for Medical Research, Kansas City, Missouri (2005.10-present).

 

PUBLICATIONS

Xia S., Dun XP, Hu PS, Kjaer S., Zheng K., Qian Y., Solén C., Xu T., Fredholm B., Hokfelt T. and Xu ZQ. Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic C terminus. Accepted by PNAS 2008.

Tofighi R., Joseph B., Xia S., Xu ZQ, Hamberger B., Hokfelt T., Ceccatelli S. Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2).  PNAS 2008 105: 2717-2722.

Xia S, Kjær S, Zheng K, Hu P, Xu T, Hokfelt T, and Xu ZQ. Constitutive and ligand-induced internalization of EGFP-tagged galanin R2 and R1 receptors in PC12 cells. Neuropeptides. 2005 Jun; 39(3):173-8.

 

Zheng K, Kuteeva E, Xia S, Bartfai T, Hokfelt T, Xu ZQ. Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice. Neuropeptides. 2005 Jun;39(3):259-67.

 

Lundstrom L, Sollenberg U, Brewer A, Kouya P F, Zheng K, Xu X-J, Xia S, Robinson J K, Zsusanna W-H, Xu Z-Q, Hokfelt T, Bartfai T, and Langel U. A galanin receptor subtype 1 specific Agonist. International Journal of Peptide Research and Therapeutics. 2005 Mar; 11(1): 15-25.

Li CH, Bai L, Li DD, Xia S, Xu T. Dynamic tracking and mobility analysis of single GLUT4 storage vesicle in live 3T3-L1 cells. Cell Res. 2004 Dec;14(6):480-6.

Xia S, Kjær S, Zheng K, Hu P, Bai L, Jia J, Rigler R, Pramanik A, Xu T, Hokfelt T, and Xu ZQ. Visualization of a functionally enhanced GFP-tagged, galanin R2 receptor in PC12 cells: constitutive and ligand-induced internalization. PNAS 2004; 101(42): 15207–15212

 

Xia S, Xu L, Bai L, Xu D Z-Q, Xu T. Labeling and dynamic imaging of synaptic vesicle-like microvesicles in PC12 cells. Brain Research 2004; 997(2):159-64.

 

Wu Z X, Xia S, Xu L, Bai L, Xu T. Dynamic Imaging of Single Secretory Granules in Live PC12 cells. Acta Bioch Bioph Sin 2003; 35: 381-386.

Xia S, Ye F, Mei X.Construction of Adenoviral Shuttle vector with p53 and p21. J. Huazhong Univ. of Sci. & Tech., 2001, Vol.29 Sup.I :58-60.

Xia S, Ye F, Mei X, Hong Q. Construction of p53 Recombinant Adenovirus Vector. J. Huazhong Univ. of Sci. & Tech., 2001, Vol.29 Sup.I :55-57.

Hong Q, Xia S, Mei X. Progress In Biotechnology. Major Problem and Their Solution in Current Tumor Gene Therapy. 2000,Vol.20 No.4:72-74.

Luo Z, Xia S, Zhang Q, Yang Z. The Expression of Green Fluorescent Protein Gene in Tobacco Plant. J. Huazhong Univ. of Sci. & Tech., 1999,Vol.27 No.9: 64-66.

Yang Z, Luo Z, Xia S, Zhou W. Construction of an Expression Plasmid With a Maize Organ-specific Promoter. J. of Hubei Univ., 1998, Vol.20 No.3: 284-287.

 

PRESENTATIONS

Visualization of a functionally enhanced GFP-tagged, galanin R2 receptor in PC12 cells: constitutive and ligand-induced internalization. EMBO World Program Fellows Meeting 2003, Heidelberg, Germany (2004.6).

Ligand-induced internalization of EGFP-tagged galanin R1 receptor in PC12 and HEK293 cells. The 15th European Neuropeptide Club Annual Meeting, Riga, Latvia (2005.5).

Constitutive and ligand-induced internalization of EGFP-tagged galanin R2 and R1 receptors in PC12 cells.  Karolinska Institute Neuroscience Annual Meeting 2005, Stockholm, Sweden (2005).