Publications

The Stowers Institute For Medical Research

PUBLICATIONS

Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A and Ma J-X. (2011) RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Developmental Biology (in press). Abstract

Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G (2011). Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids (in press). Abstract

Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Flexibility of Neural Stem Cells. Frontiers in Physiology 2:16. Abstract

Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A.(2011). The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research. Developmental Biology 355 (2):175-182. Abstract

Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A , and Duester, G. (2011). Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing. Developmental Dynamics 240(5):1142-1150. Abstract

Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A (2011). A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis 49(4):342-359. Abstract

Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Electroporation of Chick and Mouse Embryos. In: Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.

Trainor, P.A. (2010). Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention. Am J Med Genet A. 152A(12):2984-94. Abstract

Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010)
Cardiac Neural crest Cells. In: Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.

Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. Dynamic imaging of mammalian neural tube closure. Dev Biol. 2010;344:941-947. Abstract

Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development.2009;136:2329-2334. Abstract

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol.2009;330:21-31. Abstract

Sakai D, Trainor PA. Treacher Collins syndrome: Unmasking the role of Tcof1/treacle. Int J Biochem Cell Biol.2009;41:1229-1232. Abstract

Trainor PA, Dixon J, Dixon MJ. Treacher Collins syndrome: etiology, pathogenesis and prevention. Eur J Hum Genet.2009;17:275-283. Abstract

Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis. Development.2008;135:3007-3011. Abstract

Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med.2008;14:125-133. Abstract Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6. Abstract

Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Development.2008;135:729-741. Abstract

Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev.2007;21:1113-1124. Abstract

Crane JF, Trainor PA. Neural Crest Stem and Progenitor Cells. Annu Rev Cell Dev Biol.2006;22:267-286. Abstract

Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities. Proc Natl Acad Sci U S A.2006;103:13403-13408. Abstract

Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell.2006;10:355-366. Abstract

Noden DM, Trainor PA. Relations and interactions between cranial mesoderm and neural crest populations. J Anat.2005;207:575-601. Abstract

Kulesa P, Ellies DL, Trainor PA. Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis. Dev Dyn.2004;229:14-29. Abstract

Iulianella A, Melton KR, Trainor PA. Somitogenesis: breaking new boundaries. Neuron.2003;40:11-14. Abstract

Iulianella A, Vanden Heuvel G, Trainor PA. Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia. Gene Expr Patterns.2003;3:571-577. Abstract

Trainor, PA. Development. The bills of qucks and duails. Science. 2003;299:523-524.

Trainor PA, Krumlauf R. Riding the crest of Wnt signaling. Science. 2002;297:781-783.

Trainor PA, Ariza-McNaughton L, Krumlauf R. Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning. Science. 2002;295: 1288-1291. Comments about this paper may be found in Nature Reviews Neuroscience 3:254 and Nature 416: 493-494. To link to the Nature commentary, you must register with their site (free account).

Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways. Development. 2002;129: 433-442. Abstract.

Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest. Development. 2001;125:3017-3027. Abstract.

Trainor PA, Krumlauf R. Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression. Nature Rev Neurosci. 2000;1:116-124. Abstract.

Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head. Nature.2000;408:854-857. Abstract

Manzanares M, Trainor PA*, Ariza-McNaughton L, Nonchev S, Krumlauf R. Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant. Mech Dev.2000;94:147-156. Abstract

Golding JP, Trainor PA*, Krumlauf R, Gassmann M. Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nat Cell Biol.2000;2:103-109. Abstract

Trainor PA, Krumlauf R. Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm. Nat Cell Biol.2000;2:96-102. Abstract