1995: B.S. in Biology, Union College,
Schenectady, NY.
2002: Ph.D. in Biochemistry, Cellular and
Molecular Biology, Johns Hopkins University School of Medicine,
Baltimore, MD.
Awards
2003 Damon Runyon
Cancer Research Foundation Post-doctoral Fellowship (2003-2005)
1995 Phi Beta Kappa
Publications
Oca
de Montes R, Lee KK, Wilson KL.
Binding Of Barrier-to-Autointegration Factor (BAF) To Histone H3 and
Selected
Linker Histones Including H1.1. Submitted to J. Biol. Chem.
Lee,
KK, Florens
L, SwansonSK, Washburn MP,
Workman JL.The Deubiquitylation
Activity of Ubp8 is dependent upon Sgf11 and its association with the
SAGA
Complex.Mol Cell Biol.2005
Feb;25(3):1173-82.
Lee KK, Prochasson P,
Swanson SK, Florens L, Washburn M, Workman, JL. Proteomic Analysis of
Chromatin
Modifying Complexes in S. cerevisiae
Identifies Novel Subunits. Accepted for publication in Biochem.
Soc. Trans. 2004
Dec; 32
(Pt 6):899-903.
Lee KK, Wilson KL. All in the
family: evidence for four new LEM-domain proteins Lem2 (NET-25), Lem3,
Lem4 and
Lem5 in the human genome. In: The Nuclear Envelope,
Evans, D.E., Bryant, J.A., Hutchinson, C. (eds), Garland/Bios
Scientific Publishers,
Abingdon, pp 331-42.
Fridkin
A, Mills E, Margalit A, Neufeld E, Lee
KK, Feinstein N, Cohen M, Wilson KL, Gruenbaum Y. Matefin, a
Caenorhabditis
elegans germ line-specific SUN-domain nuclear membrane protein, is
essential
for early embryonic and germ cell development. Proc
Natl Acad Sci U S A. 2004 May
4;101(18):6987-92. Epub 2004 Apr 20.
Mansharamani
M, Graham DR, Monie D, Lee KK,
Hildreth JE, Siliciano RF, Wilson KL. Barrier-to-autointegration factor
BAF
binds p55 Gag and matrix and is a host component of human
immunodeficiency
virus type 1 virions. J Virol. 2003
Dec;77(24):13084-92.
Liu
J, Lee KK, Segura-Totten M, Neufeld
E, Wilson KL, Gruenbaum Y. MAN1 and emerin have overlapping function(s)
essential
for chromosome segregation and cell division in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 2003 Apr
15;100(8):4598-603. Epub 2003 Apr 08.
Holaska
JM, Lee KK, KowalskiAK, Wilson KL.
Transcriptional repressor germ cell-less (GCL) and barrier to
autointegration
factor (BAF) compete for binding to emerin in vitro. J
Biol Chem. 2003 Feb
28;278(9):6969-75. Epub 2002 Dec 18.
Mislow
JM, Holaska JM, Kim MS, Lee KK,
Segura-Totten M, Wilson KL, McNally
EM. Nesprin-1alpha self-associates and binds directly to emerin and
lamin A in
vitro. FEBS
Lett. 2002 Aug
14;525(1-3):135-40.
Lee KK, Starr D,
Cohen M, Liu J, Han M, Wilson KL, Gruenbaum Y. Lamin-dependent
localization of
UNC-84, a protein required for nuclear migration in Caenorhabditis
elegans. Mol Biol Cell. 2002 Mar;13(3):892-901.
Lee
KK, Gruenbaum
Y*, Liu
J, Cohen M, Wilson KL. The
expression, lamin-dependent localization and RNAi depletion phenotype
for
emerin in C. elegans. J Cell Sci.
2002 Mar 1;115(Pt 5):923-9. (* shared first authorship)
Haraguchi
T, Koujin T, Segura-Totten M, Lee KK,
Matsuoka Y, Yoneda Y, Wilson KL, Hiraoka Y. BAF is required for emerin
assembly
into the reforming nuclear envelope. J
Cell Sci. 2001 Dec;114(Pt
24):4575-85.
Lee KK, Haraguchi T,
Lee RS, Koujin T, Hiraoka Y, Wilson KL. Distinct functional domains in
emerin
bind lamin A and DNA-bridging protein BAF. J
Cell Sci. 2001 Dec;114(Pt 24):4567-73.
Shumaker
DK, Lee KK, Tanhehco YC, Craigie R, Wilson KL. LAP2 binds
to BAF.DNA complexes: requirement for the LEM domain and modulation by
variable
regions. EMBO
J. 2001 Apr 2;20(7):1754-64.
Wilson KL, Zastrow
MS, Lee KK. Lamins and disease:
insights into nuclear infrastructure. Cell.
2001 Mar 9;104(5):647-50.
Lee KK, Cohen M*, Wilson
KL, Gruenbaum Y. Transcriptional repression, apoptosis, human disease
and the
functional evolution of the nuclear lamina. Trends Biochem
Sci. 2001 Jan;26(1):41-7. (* shared first
authorship)
Lee KK, Gruenbaum Y,
Spann P, Liu J, Wilson KL. C. elegans
nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal
unique
timing of nuclear envelope breakdown during mitosis. Mol
Biol Cell. 2000 Sep;11(9):3089-99.
Desilva
H, Lee K, Osley MA. Functional
dissection of yeast Hir1p, a WD repeat-containing transcriptional
corepressor. Genetics. 1998 Feb;148(2):657-67.
Spector
MS, Raff A, DeSilva H, Lee K, Osley
MA. Hir1p and Hir2p function as transcriptional corepressors to
regulate
histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol. 1997 Feb;17(2):545-52.