Contact Information:

Education:

Tokyo Medical and Dental University, Tokyo, Japan

Ph.D., Molecular Embryology 2001

Publications:

1) Suganuma, T. and Workman, J. L. (2011) Combinatorial Functions of Histone

Modifications. Annual Review of Biochemistry 80 (29), 21-29.27.

2) Suganuma, T., Mushegian, A., Swanson, S. K.,  Abmayr, S. M., Florens, L., Washburn, Michael P.,  and Workman, J. L. The ATAC Acetyltransferase Complex Coordinates MAP kinases to regulate JNK Target Genes. Cell 142, 726-736.

3) Suganuma, T and Workman, J. L. (2010)  Features of the PHF8/KIAA1718 histone demethylase. Research Highlight, Cell Research 20 (8).

4) Suganuma, T and Workman, J. L. (2009) WD40 Repeats Arrange Histone Tails for Spreading of Silencing. Research Highlight, Journal of Molecular Cell Biology, 1-3.

5) Suganuma, T. and Ikeda, MA. (2008) Tumor Growth Suppression by the Coactivator p300. Review, Journal of Oral Bioscience 50 (2), 115-124.

6) Suganuma, T. and Workman, J. L. (2008) Crosstalk Among Histone Modifications. Minireview. Cell 135, 604-607.

7) Suganuma, T., Pattenden, S. G., and Workman, J. L. (2008) Diverse functions of WD40 repeat proteins in histone recognition. Perspective. Genes & Development 22, 1265-1268.

8) Suganuma, T., Guttierres, J., Li, B., Florens, L., Swanson, S. K., Washburn, M. P., and Workman. J. L. (2008) ATAC is a Double Histone Acetyltransferase Complex that Stimulates Nucleosome Sliding. nature structural & molecular biology 15 (4), 364-372.

9) Guelman, S., Suganuma, T., Florens, L., Weake, V., Swanson, S. K.,Washburn, M. P., Abmayr, S. M., and Workman, J. L. (2006) The Essential Gene wda Encodes a WD40 Repeat Subunit of Drosophila SAGA Required for Histone H3 Acetylation, Molecular and Cellular Biology 26 (19), 7178-7189.

10) Guelman, S., Suganuma, T., Florens, L., Swanson, S. K., Kiesecker, C. L., Kush, T., Anderson, S., Yates III, J. R., Washburn, M. P., Abmayr, S. M., and Workman, J. L., (2006) Host Cell Factor and an Uncharacterized SANT Domain Protein Are Stable Components of ATAC, a Novel dAda2a/ dGcn5-Containing Histone Acetyltransferase Complex in Drosophila. Molecular and Cellular Biology 26 (3), 871-882.

11) Carrozza, M. J., Li, B., Florens, L., Suganuma, T., Swanson, S. K., Lee, K. K., Shia, W., Anderson, S., Yates, J., Washburn, M. P., and Workman, J. L., (2005) Histone H3 Methylation by Set2 Directs Deacethylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription, Cell 123, 581-592.

12) Ma, K., Araki, K., Ichwan, A. J., S., Suganuma, T., Tamamori, MA., and Ikeda, MA. (2003) E2FBP1/DRIL1, an AT-Rich Interaction Domain-Family Transcription Factor, Is Regulated by p53. Molecular Cancer Research 1, 438-444.

13) Suganuma, T., Kawabata, M., Ohshima, T., Ikeda, MA. (2002) Growth Suppression of human carcinoma cells by reintroduction of the p300 coactivator. Proc Natl Acad Sci U S A 99(20):13073-8.

14) Suganuma, T., (2002) Effect of Mutation in the p300 Transcription Coactivator on Transcriptional Response and Cell Proliferation of Human Carcinoma Cell Lines. The Journal of the Stomatological Society, Japan 69 (2), 139-151.

15) Ohshima, T.*, Suganuma, T.*, Ikeda, MA. (2001). A Novel Mutation Lacking the Bromodomain of the Transcriptional Coactivator p300 in the SiHa Cervical Carcinoma Cell Line. Biochemical Biophysical Research Communications 281, 569-575. *These authors contributed equally to this work.

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