Zeitlinger Lab ~ Research
Transcription regulatory networks in Drosophila development |
|---|
Human disease is frequently associated with aberrant signal transduction components, DNA-binding transcription factors and chromatin modifying enzymes, yet how these components regulate specific biological outcomes is largely unknown. There is therefore a critical need to understand how regulatory proteins affect global gene expression and cellular behavior in a context-specific manner. The long-term goal of our research is to identify predictive rules by which gene expression programs are established in an organism and apply them to human disease. It is known that gene expression programs are specified by signal transduction pathways that are activated by signals from neighboring cells during development. However, how these signal transduction pathways regulate gene expression is highly context-dependent. Based on current knowledge, gene regulation depends on two principles, combinatorial regulation and (epigenetic) cellular memory. We are studying both principles in Drosophila using genome-wide techniques that map protein-DNA interaction, expression analysis, computational methods and classical Drosophila genetics. |
Zeitlinger Lab Stowers Institute for Medical Research 1000 East 50th Street Kansas City, MO 64110 [T] 816.926.4487 [F] 816.926.2071 |
 |